Article

Intravascular large B-cell lymphoma with preceding syndrome of inappropriate secretion of antidiuretic hormone.

Department of Internal Medicine, Keio University School of Medicine, Tokyo.
Internal Medicine (impact factor: 0.94). 02/2007; 46(18):1569-72. pp.1569-72
Source: PubMed

ABSTRACT Intravascular large B-cell lymphoma (IVL) is a rare subtype of B-cell lymphoma presenting with neurological and dermatological lesions in addition to generalized symptoms such as fever and malaise. It may also be associated with variable manifestations of affected organs due to extranodal progression predominantly in the lumen of the small vessels. Here, we report a case of IVL with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) as the sole manifestation at the initial presentation. The present case suggests that hormonal disturbances may progress in advance in IVL, before generalized symptoms develop.

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Keywords

antidiuretic hormone
 
extranodal progression
 
generalized symptoms
 
inappropriate secretion
 
initial presentation
 
Intravascular large B-cell lymphoma
 
IVL
 
present case
 
rare subtype
 
SIADH
 
small vessels
 
sole manifestation
 
variable manifestations
 

Kokichi Morimoto