Treatment of psychiatric symptoms associated with neurosyphilis

Albert Einstein Medical Center, Filadelfia, Pennsylvania, United States
Psychosomatics (Impact Factor: 1.67). 09/2007; 48(5):440-5. DOI: 10.1176/appi.psy.48.5.440
Source: PubMed

ABSTRACT There is currently no consensus on how to manage the psychiatric manifestations of neurosyphilis, despite the resurgence of this condition. The authors present five cases of neurosyphilis in inpatient psychiatric settings that manifested with predominantly psychiatric symptoms and were appropriately diagnosed and successfully treated with psychotropic medication concurrent with antibiotic therapy. A review of available data reveals that presently there are no specific guidelines to address psychiatric symptomatology in neurosyphilis. The authors see merit in the prudent use of psychotropic medication to achieve symptom stabilization.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Neurosyphilis may presents with a range of psychiatric symptoms. This report illustrates a case of neurosyphilis in a man who presented with psychosis and cognitive dysfunction. Clinical findings and investigations done in the present case showed positive results for syphilis. Reduction of symptoms was noted after treatment with antibiotic. This case further highlights the importance of having high index of suspicion for neurosyphilis in patients presenting with psychiatric symptoms.
    Asia-Pacific Psychiatry 04/2013; 5(S1). DOI:10.1111/appy.12050 · 0.42 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A 15-year-old girl with neurosyphilis was misdiagnosed as having viral encephalitis with psychotic symptoms and Parkinsonism. We found that she was experiencing visual hallucinations, persecutory delusions, flattening of affect, poorness of thought, tremors, four-limb rigidity, and restlessness, and she was unable to communicate with others. The Venereal Disease Research Laboratory serum test and further lumbar puncture enabled us to diagnose her with neurosyphilis. After antibiotic treatment, her psychotic symptoms and Parkinsonism were relieved. From this case, we believe that it is important to keep organic psychosis in mind during the diagnostic workup, and we argue that routine syphilis screening is necessary in psychiatry clinical practice.
    Neuropsychiatric Disease and Treatment 02/2015; 11:375-7. DOI:10.2147/NDT.S76897 · 2.15 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective: To describe a case of neurosyphilis presenting with treatment-resistant psychotic symptoms (which responded to antibiotic treatment) and cognitive dysfunction. Method: A single case report. Results: We describe the case of a sixty nine year old man, presenting with psychotic symptoms characterised by perse- cutory delusions and olfactory hallucinations, and deterioration in cognitive functions. He had late latent syphilis re- vealed by specific serological investigation. CT scan revealed mild cortical atrophy. The psychotic symptoms did not re- spond to antipsychotic treatment, however improved following treatment with antibiotics. Conclusion: This case emphasizes the need to exclude organic causes especially in patients whose symptoms resistant to treatment (German J Psychiatry 2008; 11: 153-155).