Treatment of Psychiatric Symptoms Associated With Neurosyphilis

Albert Einstein Medical Center, Filadelfia, Pennsylvania, United States
Psychosomatics (Impact Factor: 1.86). 09/2007; 48(5):440-5. DOI: 10.1176/appi.psy.48.5.440
Source: PubMed


There is currently no consensus on how to manage the psychiatric manifestations of neurosyphilis, despite the resurgence of this condition. The authors present five cases of neurosyphilis in inpatient psychiatric settings that manifested with predominantly psychiatric symptoms and were appropriately diagnosed and successfully treated with psychotropic medication concurrent with antibiotic therapy. A review of available data reveals that presently there are no specific guidelines to address psychiatric symptomatology in neurosyphilis. The authors see merit in the prudent use of psychotropic medication to achieve symptom stabilization.

3 Reads
  • Source
    • "The CT scan in our patient revealed cortical atrophy, which was in keeping with published literature (Holland,1986; Pavitharan,1993 and G├╝rses, 2007). Psychiatric symptoms improved with addition of antibiotic therapy to his antipsychotic medication, similar to the case series by Sanchez (2007). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective: To describe a case of neurosyphilis presenting with treatment-resistant psychotic symptoms (which responded to antibiotic treatment) and cognitive dysfunction. Method: A single case report. Results: We describe the case of a sixty nine year old man, presenting with psychotic symptoms characterised by perse- cutory delusions and olfactory hallucinations, and deterioration in cognitive functions. He had late latent syphilis re- vealed by specific serological investigation. CT scan revealed mild cortical atrophy. The psychotic symptoms did not re- spond to antipsychotic treatment, however improved following treatment with antibiotics. Conclusion: This case emphasizes the need to exclude organic causes especially in patients whose symptoms resistant to treatment (German J Psychiatry 2008; 11: 153-155).
    German Journal of Psychiatry 12/2008; 11(4).
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Among the critically ill, infectious diseases can play a significant role in the etiology of neuropsychiatric disturbances. All critical care physicians are familiar with delirium as a secondary complication of systemic infection. This article focuses on key infectious diseases that commonly and directly produce neuropsychiatric symptoms, including direct infection of the central nervous system.
    Critical Care Clinics 11/2008; 24(4):889-919, x. DOI:10.1016/j.ccc.2008.05.007 · 2.16 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Recent surveys have assessed a remarkable increase in the prevalence of infectious syphilis. If left untreated, 30% of patients may develop tertiary syphilis, which can manifest as neurosyphilis. The authors present a case of an acute psychosis during and after pregnancy in a 37-year-old woman, which was identified as a manifestation of neurosyphilis after admission to a psychiatric ward. The positive screening test for syphilis provided the first hint of syphilis and gave direction for further diagnosis and specific treatment. Subsequently, the patient was treated with psychotropic medication concurrent with an adequate antibiotic treatment for neurosyphilis and was simultaneously psychologically monitored. An improvement of psychotic symptoms during antibiotic therapy was observed. This case emphasises that neurosyphilis still has to be considered in the differential diagnosis within the context of psychiatric conditions and diseases. Owing to current epidemiological data and difficulties in diagnosing syphilis, routine screening tests in the psychiatric field are necessary.
    General hospital psychiatry 07/2009; 31(4):379-81. DOI:10.1016/j.genhosppsych.2008.09.010 · 2.61 Impact Factor
Show more

Similar Publications