Article

Identification of nyasol and structurally related compounds as the active principles from Anemarrhena asphodeloides against respiratory syncytial virus (RSV).

The Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Chemistry & Biodiversity (impact factor: 1.8). 10/2007; 4(9):2231-5. DOI:10.1002/cbdv.200790181 pp.2231-5
Source: PubMed

ABSTRACT Three known phenolic compounds, (-)-(R)-nyasol (= 4,4'-(1Z,3R)-Penta-1,4-diene-1,3-diyldiphenol; 1), its derivative 2, and broussonin A (3)--isolated from the rhizomes of Anemarrhena asphodeloides--were for the first time identified as the active principles capable of efficient respiratory-syncytial-virus (RSV) inhibition. The IC50 values of 1-3 against the RSV-A2 strain, propagated in HEp-2 cells, were determined, their activities being higher than that of the standard antiviral drug ribavirin (IC50 = 1.15 microM). In addition, the known, but inactive, compound 'trans-N-(para-coumaroyl)tyramine' (= (2E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide; 4) was isolated from this plant for the first time.

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Keywords

-)-(R)-nyasol
 
2E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide
 
active principles capable
 
compound 'trans-N-(para-coumaroyl)tyramine'
 
efficient respiratory-syncytial-virus
 
HEp-2 cells
 
IC50 values
 
phenolic compounds
 
propagated
 
rhizomes
 
standard antiviral drug ribavirin
 

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