Article

Prevalence of ETV6-RUNX1 fusion gene in children with acute lymphoblastic leukemia in China.

Division of Hematology/Oncology, Children's Hospital Fudan University, 183 Fenglin Road, Shanghai 200032, China.
Cancer Genetics and Cytogenetics (impact factor: 1.39). 11/2007; 178(1):57-60. DOI:10.1016/j.cancergencyto.2007.05.019 pp.57-60
Source: PubMed

ABSTRACT A series of 92 Chinese children newly diagnosed with acute lymphoblastic leukemia (ALL) were examined for the ETV6-RUNX1 (previously TEL-AML1) fusion gene by using a nested reverse transcriptase-polymerase chain reaction. ETV6-RUNX1 fusion transcripts were detected in 21 of 92 patients (22.8%): 16 with common ALL, 4 with precursor B-cell ALL, and 1 with T-ALL. The prevalence of ETV6-RUNX1 positivity was 24.7% (20/81) in childhood B-lineage ALL. The prevalence of ETV6-RUNX1 in Chinese pediatric ALL patients proved to be similar to that found in other countries.

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Keywords

92 Chinese children
 
childhood B-lineage
 
Chinese pediatric
 
countries
 
nested reverse transcriptase-polymerase chain reaction
 
precursor B-cell
 
prevalence
 
TEL-AML1
 

Yi-Jin Gao