Article

Framework for metals risk assessment.

Office of the Science Advisor, Risk Assessment Forum, US Environmental Protection Agency, Washington, DC 20460, USA.
Ecotoxicology and Environmental Safety (Impact Factor: 2.48). 11/2007; 68(2):145-227. DOI: 10.1016/j.ecoenv.2007.03.015
Source: PubMed

ABSTRACT EPA recognized that metals present unique risk assessment issues, and saw the need to develop a framework document that puts forth key scientific principles for metals risk assessments to help ensure consistency in metals assessments across EPA programs and regional offices. This framework, called the "Framework for Metals Risk Assessment," is a science-based document that describes basic principles that address the special attributes and behaviors of metals and metal compounds to be considered when assessing their human health and ecological risks. The Risk Assessment Forum oversaw the development of this document, including input from stakeholders and experts throughout the Agency, and obtained through several expert workshops, followed by peer review by the EPA Science Advisory Board (SAB). The Framework for Metals Risk Assessment document is intended to serve as a guide for all EPA programs and regional offices to supplement or update the policies, practices and guidance they currently use in their respective metals assessments. This framework document is not a prescriptive guide on how any particular type of assessment should be conducted within an EPA program office. Rather, it outlines key metal principles and describes how they should be considered in conducting human health and ecological risk assessments to advance our understanding of metals impact and foster consistency across EPA programs and regions. Although the audience for the framework is primarily intended to be Agency risk assessors, it also will communicate principles and recommendations for metals risk assessment to stakeholders and the public. This framework will be used in conjunction with guidance developed by the programs and regions for site-specific risk assessment, criteria derivation, ranking or categorization and other similar Agency activities related to metals. The Framework for Metals Risk Assessment document is intended to serve as a guide for all EPA programs and regional offices to supplement or update the policies, practices and guidance they currently use in their respective metals assessments. EPA assessments can vary in level of detail from simple, screening analyses to complex, definitive assessments. More complex scientific tools and metal specific methods should be applied as the complexity of the hazard assessment or risk assessment increases.

1 Bookmark
 · 
156 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Concentrations of copper, lead and zinc in sediments downstream of a metallurgical facility on the the Upper Columbia River (UCR) were significantly greater than those in regional reference locations. Sturgeons inhabit benthic habitats and there is concern that they might be at greater risk of exposure. A laboratory based, flow-through, experimental exposure system was used to characterize toxicity of metals in the different matrices associated with sediments collected from the UCR, and to assess risk to early life stages of white sturgeon (Acipenser transmontanus) under chronic bioassay conditions. Bioavailability and concentrations of metals in pore water, overlying water, and at the sediment-water interface were characterized. Several sampling methods including peepers, diffusive gradients in thin films (DGTs), and active sampling/suction techniques were employed. Results indicated that concentrations of metals in site sediments were significantly greater in comparison to upstream reference sediments. Of the four primary metals of concern, concentrations of copper, primarily in pore water, were significantly greater in exposure chambers containing site sediments compared to reference sediments. In addition, the different sampling techniques resulted in varying estimates of concentration depending on matrix, analyte, and method, and the present study highlights challenges in assessing the true risk of exposure. The analytical data reported herein is utilized in a parallel article to characterize risk and compare predictions to the bioassay results.
  • [Show abstract] [Hide abstract]
    ABSTRACT: In order to make people aware of the contamination of heavy metals in our daily life by inappropriate food intake, we have studied the contents of copper, cadmium, and lead in various components of our biota (soil, water, and plants, i.e. fruits and vegetables), collected from different areas (normal, industrial, coal-mine, river, and hill areas). For the accurate and rapid sensing of these metal ions, a multi-template imprinted nanowire modified electrochemical sensor was reported. The imprinted nanowire was synthesized using multiwalled carbon nanotubes as a core, on which a layer of conducting polyarginine is cast using an electro-polymerization technique. To study the total uptake of food-borne Cu(II), Cd(II), and Pb(II) ions in the human body, blood samples of six people were taken based on their different diets in their daily routine. Moreover, during the soil, water and plant analysis, it was observed that plants growing in a contaminated environment have a large accumulation of metal ions in their leaves and fruits. One more study was performed to explore ‘how much heavy metal we are taking in from our regular diet?’ and it was perceived that some of the food, which has lower concentrations of copper ions, can release a bigger amount of metal ions after digestion.
    RSC Advances 10/2014; 4(100). DOI:10.1039/C4RA08875A · 3.71 Impact Factor
  • Canadian Journal of Fisheries and Aquatic Sciences 10/1984; 41(10):1463-1472. DOI:10.1139/f84-180 · 2.28 Impact Factor

Full-text

Download
30 Downloads
Available from
May 31, 2014