Article

RamB is an activator of the pyruvate dehydrogenase complex subunit E1p gene in Corynebacterium glutamicum.

Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany.
Journal of Molecular Microbiology and Biotechnology (impact factor: 1.95). 10/2007; 16(3-4):236-9. DOI:10.1159/000108782 pp.236-9
Source: PubMed

ABSTRACT In Corynebacterium glutamicum, the transcriptional regulator RamB negatively controls the expression of genes involved in acetate metabolism. Here we show that during growth in media containing glucose and in complex medium without glucose RamB activates expression of the aceE gene, encoding the E1p subunit of the pyruvate dehydrogenase complex. Thus, RamB functions both as repressor and as activator in C. glutamicum.

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Keywords

aceE gene
 
acetate metabolism
 
activator
 
complex medium
 
genes
 
glucose RamB activates expression
 
pyruvate dehydrogenase complex
 
RamB functions
 
transcriptional regulator RamB