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Biflavones of Decussocarpus rospigliosii as phosphodiesterases inhibitors.

LC1 UMR-CNRS 7175 Biotechnologies, Biomolécules et Innovations Thérapeutiques, Faculté de Pharmacie de Strasbourg, Illkirch, France.
Planta Medica (Impact Factor: 2.35). 11/2007; 73(12):1284-6. DOI: 10.1055/s-2007-990218
Source: PubMed

ABSTRACT A phytochemical study of an ethyl acetate extract of Decussocarpus rospigliosii leaves led to the isolation of six 3'-8''-biapigenin derivatives identified as amentoflavone (1), podocarpusflavone A (2), sequoiaflavone (3), podocarpusflavone B (4), 7,7''-di-O-methylamentoflavone (5) and heveaflavone (6). Biflavones 1-4 showed strong inhibitory activity on several PDE isoforms. Biflavone (5) showed selective and potent inhibition of the PDE4 isoform (IC50=1.48+/-0.21 microM) and was almost as active as the reference drug Rolipram (IC50=1.1+/-0.2 microM).

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