Biflavones of Decussocarpus rospigliosii as phosphodiesterases inhibitors

University of Strasbourg, Strasburg, Alsace, France
Planta Medica (Impact Factor: 2.15). 11/2007; 73(12):1284-6. DOI: 10.1055/s-2007-990218
Source: PubMed


A phytochemical study of an ethyl acetate extract of Decussocarpus rospigliosii leaves led to the isolation of six 3'-8''-biapigenin derivatives identified as amentoflavone (1), podocarpusflavone A (2), sequoiaflavone (3), podocarpusflavone B (4), 7,7''-di-O-methylamentoflavone (5) and heveaflavone (6). Biflavones 1-4 showed strong inhibitory activity on several PDE isoforms. Biflavone (5) showed selective and potent inhibition of the PDE4 isoform (IC50=1.48+/-0.21 microM) and was almost as active as the reference drug Rolipram (IC50=1.1+/-0.2 microM).

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    • "Some of the pharmacological properties attributed to biflavonoids include antiviral, anti-inflammatory, antimicrobial and anti-cancer activities (Mkounga et al., 2009; Pang et al., 2009). Biflavonoids are also known as cyclic nucleotide phosphodiesterase inhibitors (Chaabi et al., 2007; Harborne, 1986). "
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