Article

Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.

Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Journal of Pharmacological Sciences (impact factor: 2.08). 10/2007; 105(1):122-6. pp.122-6
Source: PubMed

ABSTRACT We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.

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    Article: Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand.
    Wolfgang Stuetz, Tippawan Prapamontol, Surat Hongsibsong, Hans-Konrad Biesalski
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    Journal of Agricultural and Food Chemistry 05/2010; 58(10):6069-74. · 2.82 Impact Factor
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Keywords

11-day administration
 
acetylcholinesterase
 
Alzheimer's disease
 
ChAT
 
ChAT expression
 
choline acetyltransferase
 
citrus flavonoid
 
major clinical features
 
nobiletin
 
nobiletin rescues OBX-induced cholinergic neurodegeneration
 
OBX-induced cholinergic neurodegeneration
 
olfactory-bulbectomized
 
useful paradigm