Article

Genetic and phenotypic stability of measures of neuroticism over 22 years.

Genetic Epidermology, Queensland Institute of Medical Research, Brisbane, Australia.
Twin Research and Human Genetics (Impact Factor: 1.92). 11/2007; 10(5):695-702. DOI: 10.1375/twin.10.5.695
Source: PubMed

ABSTRACT People meeting diagnostic criteria for anxiety or depressive disorders tend to score high on the personality scale of neuroticism. Studying this dimension of personality can therefore give insights into the etiology of important psychiatric disorders. Neuroticism can be assessed easily via self-report questionnaires in large population samples. We have examined the genetic and phenotypic stability of neuroticism, measured up to 4 times over 22 years, on different scales, on a data set of 4,999 families with over 20,000 individuals completing at least 1 neuroticism questionnaire. The neuroticism scales used were the Eysenck Personality Questionnaire revised (EPQ-R), the EPQ-R shortened form, and the NEO 5 factor inventory personality questionnaire. The estimates of heritability of the individual measures ranged from .26 +/- .04 to .36 +/- .03. Genetic, environmental, and phenotypic correlations averaged .91, .42, and .57 respectively. Despite the range in heritabilities, a more parsimonious 'repeatability model' of equal additive genetic variances and genetic correlations of unity could not be rejected. Use of multiple measures increases the effective heritability from .33 for a single measure to .43 for mean score because of the reduction in the estimate of the environmental variance, and this will increase power in genetic linkage or association studies of neuroticism.

0 Bookmarks
 · 
85 Views
  • Source
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Several studies have demonstrated a strong overlap in variance between the salutogenic construct Sense of Coherence (SOC) and the Big Five personality traits, yet the unique contributions of these overlapping constructs remain debated. Specifically, the statistical association between SOC and neuroticism has been taken as evidence for SOC representing a fundamental personality trait in disguise. The present research explored the incremental validity when predicting crucial psychological outcomes: mental health, satisfaction with life, and psychological distress.
    Personality and Individual Differences 04/2015; 77. DOI:10.1016/j.paid.2014.12.053 · 1.86 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Introduction: Neuroticism is an important marker of vulnerability for both mental and physical disorders. Its link with multiple etiological pathways has been studied before. Inflammatory markers have been demonstrated to predict similar mental and physical disorders as neuroticism. However, currently no study has focused on the shared genetic background of neuroticism and inflammatory markers. In the present study we will focus on the phenotypic and genetic relationship between neuroticism and three commonly used inflammatory markers: C-reactive protein (CRP), fibrinogen and Immunoglobulin-G (IgG). Material and Methods: The study was conducted in 125 Dutch female twin pairs. For each participant, four different neuroticism scores were available to calculate a neuroticism composite score that was used in the statistical analyses. Blood samples for inflammatory marker determination were taken after an overnight fast. Heritabilities, phenotypic and genetic correlations were estimated using bivariate structural equation modeling. Results: Heritabilities are fair for neuroticism (0.55), CRP (0.52) and fibrinogen (0.67) and moderate for IgG (0.43). No significant phenotypic or genetic correlations were found between neuroticism and the inflammatory markers. Interaction models yielded no moderation of the genetic and environmental pathways in the regulation of inflammatory markers by neuroticism. Conclusion: Substantial heritabilities were observed for all variables. No evidence was found for significant shared (or moderation of) genetic or environmental pathways underlying neuroticism and inflammatory status.
    Twin Research and Human Genetics 04/2014; 17(3):1-6. DOI:10.1017/thg.2014.19 · 1.92 Impact Factor

Full-text (2 Sources)

Download
46 Downloads
Available from
Jun 3, 2014