Article

Effect of metronidazole analogues on Giardia lamblia cultures.

Departamento de Parasitologia, ICB-UFMG, Av. Antônio Carlos, 6627, 31270-901, Belo Horizonte, Minas Gerais, Brazil.
Parasitology Research (impact factor: 2.15). 01/2008; 102(1):145-9. DOI:10.1007/s00436-007-0723-4 pp.145-9
Source: PubMed

ABSTRACT We comparatively evaluate the effect of metronidazole (MTZ) and its five analogues on trophozoites of Giardia lamblia axenically growing. The compounds MTZ-Ms, MTZ-I, MTZ-Br, MTZ-N(3), and MTZ-NH(3)Cl were obtained by molecular modification of the side chain of MTZ. Four of them presented higher giardicidal activity when compared with MTZ. Among them, MTZ-Br and MTZ-I were the most active, without cytotoxic effects against mitogen-activated human peripheral blood mononuclear cells (PBMC). The alteration of MTZ side chain constitutes a fruitful field to develop new drugs for the treatment not only of giardiasis but also of other diseases and signalize that metronidazole analogues are promising candidates as giardicidal and should be further evaluated.

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Keywords

active
 
compounds MTZ-Ms
 
cytotoxic effects
 
diseases
 
five analogues
 
Giardia lamblia axenically
 
giardiasis
 
giardicidal
 
higher giardicidal activity
 
mitogen-activated human peripheral blood mononuclear cells
 
molecular modification
 
MTZ
 
MTZ side chain
 
MTZ-Br
 
MTZ-I
 
new drugs
 
side chain
 

Haendel G N O Busatti