Article

Vascular tissue engineering and vascularized 3D tissue regeneration.

Nippon Medical School, Department of Plastic and Reconstructive Surgery1, 1-5 Sendagi Bunkyoku, Tokyo 113-8603, Japan.
Regenerative Medicine (impact factor: 3.72). 10/2007; 2(5):831-7. DOI:10.2217/17460751.2.5.831 pp.831-7
Source: PubMed

ABSTRACT Vascularized tissue regeneration has a great deal of potential in clinical medicine. Appropriate 3D tissue regeneration that yields tissue with the desired function and shape requires both growth signals and vascularization. In this paper, we discuss vascularized tissue regeneration using various vessel systems: artificial vessel, autologous vascular graft, autologous vascular bundle transfer and tissue engineered vessel. Vascularized 3D tissue regeneration will require a great deal of additional research before it can be applied to clinical situations. Several promising studies of vascularized tissue regeneration have been reported. However, additional studies into the maturation of neovascularization, the development of effective biomaterial, and the possibility of using stem cells will be needed before these techniques can be used in the clinical situation.

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    Article: Prefabrication of tissue engineered bone grafts: an experimental study.
    Takahisa Okuda, A Cagri Uysal, Morikuni Tobita, Hiko Hyakusoku, Hiroshi Mizuno
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    ABSTRACT: The purpose of this study was to determine whether angiogenesis could successfully be induced into bone tissue that was engineered by cultured adipose-derived stem cells with porous beta-tricalcium phosphate and whether its biologic properties could be maintained by flap prefabrication technique.Adipose-derived stem cells with porous beta-tricalcium phosphate were implanted into the superficial inferior epigastric artery flap of the Fisher rats. After prefabrication for 8 weeks, the prefabricated flaps were elevated and the pedicles were clamped for 4 hours. The samples were harvested after 2 weeks for analyses.Angiogenesis was significantly increased in the prefabricated groups (P < 0.05). There was no significant difference between the prefabricated and nonprefabricated groups in terms of the osteogenic capacity (P > 0.5).The promising results obtained with prefabrication in tissue engineered bone grafts encourage the clinical application of this technology. Thus, prefabrication may be a useful technique in any engineered bone tissue transfer.
    Annals of plastic surgery 12/2009; 64(1):98-104. · 1.29 Impact Factor
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Keywords

additional research
 
additional studies
 
artificial vessel
 
autologous vascular graft
 
clinical medicine
 
clinical situation
 
clinical situations
 
desired function
 
effective biomaterial
 
growth signals
 
neovascularization
 
various vessel systems
 
Vascularized 3D tissue regeneration
 
Vascularized tissue regeneration
 
yields tissue
 

Rei Ogawa