The role of embolic protection devices in renal artery stenting.
ABSTRACT Renal artery angioplasty and stenting is commonly performed for the treatment of hypertension and ischemic nephropathy. An increasing number of procedures are being undertaken for "renal preservation" despite an associated risk of renal function decline related to the embolization of atheromatous debris liberated during the procedure. Although smaller, more flexible guidewires and stents have been developed to decrease the amount of debris created, interest in the off-label use of embolic protection devices has increased. We review the available embolic protection devices and currently available data regarding their use in renal artery interventions. Although not designed for use in the renal artery, there are at least theoretical reasons to believe that embolic protection during renal artery angioplasty may improve outcomes.
- SourceAvailable from: Robert J MacginleyNephrology 04/2010; 15 Suppl 1:S227-33. · 1.69 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: To present clinical outcomes with the use of embolic protection devices (EPDs) and renal artery stents in patients with chronic renal insufficiency (CRI) and renal artery stenosis (RAS). A retrospective study was conducted in 23 patients with RAS and CRI who were treated with renal artery stent placement with an EPD. Follow-up data were obtained through medical records. In 23 patients (18 men; 78%) with an average age of 69.4 years +/- 11 (range, 46-86 y), 32 renal arteries were treated for worsening renal function (n = 17; 74%) or uncontrolled hypertension and worsening renal function (n = 6; 26%). Nine FilterWire EZ devices were used in eight patients (35%) and 17 SpideRX devices were used in 15 patients (65%). The average follow-up was 8 months +/- 5. After the stent procedure, the mean systolic blood pressure decreased significantly (P < .05) whereas the diastolic pressure remained unchanged. There was a significant increase in the mean estimated glomerular filtration rate from 32.9 mL/min +/- 12.9 at baseline to 41.3 mL/min +/- 13.7 at last follow-up (P < .05). In 96% of patients, there was improvement or stabilization of kidney function. In six of the 17 SpideRX devices (35%), macroscopically evident embolic material was observed in the device after stent placement. There were two minor and two major complications. Renal artery stent placement combined with the use of a SpideRX or FilterWire EZ device is associated with an good clinical outcome with a reasonable safety profile.Journal of vascular and interventional radiology: JVIR 10/2008; 19(11):1639-45. · 1.81 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: To report the off-label use of Emboshield filters as a treatment for bilateral atheroembolism (trash foot) in an inoperable patient. A 64-year-old man with a juxtarenal abdominal aortic aneurysm (jAAA) presented with necrotic wounds of the forefoot and toes of both feet. Doppler imaging showed triphasic signals. He was on oral anticoagulants because of a mechanical valve. The patient was admitted for evaluation and administration of intravenous antibiotics; other than the jAAA, no other source of emboli was detected. Since the patient was inoperable, Emboshield filters were placed bilaterally through antegrade femoral accesses at the level of the superficial femoral arteries to prevent embolism to the feet. Two years later, the patient has no symptoms; debris is present in both filters but does not compromise arterial flow into the legs. This case demonstrates the successful off-label use of an Emboshield filter for trash foot in an inoperable patient.Journal of Endovascular Therapy 06/2010; 17(3):399-401. · 2.70 Impact Factor