Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation

Department of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Phytomedicine: international journal of phytotherapy and phytopharmacology (Impact Factor: 3.13). 05/2008; 15(4):306-9. DOI: 10.1016/j.phymed.2007.08.002
Source: PubMed


Twelve compounds isolated from Alpinia mutica Roxb., Kaempferia rotunda Linn., Curcuma xanthorhiza Roxb., Curcuma aromatica Valeton and Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from A. mutica and 3-deacetylcrotepoxide from K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC(50) values of less than 84 microM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC(50) values of 37.5, 60.9 and 45.7 microM, respectively.

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    • "Presently, rhizome's extract has been extensively studied for its effectiveness in a broad range of biological activities including antimicrobial [16], antipyretic [17], antispasmodic and anticonvulsant [3], antiulcer [18], antioxidant [19], antidiabetic [20], antitumor [21], anticancer [22, 23], anti-inflammatory [24, 25], antinociceptive and analgesic [26, 27], antiallergenic [28], antiangiogenic [29], antidipogenetic [30], antiplatelet aggregation and anticoagulant [31], and hepatoprotective effects [32]. Other studies have shown that consuming the rhizome also exhibits hypolipidemic effect by reducing intestinal cholesterol absorption, which makes it useful for treating heart diseases [33, 34]. "
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    ABSTRACT: Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review of assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutica effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in treatment of malignancies using ZER.
    BioMed Research International 06/2014; 2014(920742):20 pages. DOI:10.1155/2014/920742 · 3.17 Impact Factor
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    • "Zerumbone has been demonstrated to possess in vivo antinociceptive [20] and anti-inflammatory [21] [22] [23] activities. While in the in vitro studies, zerumbone has been reported to exhibit antiproliferative [20] and antiplatelet aggregation [24] activities. In our laboratory we have also found the antistaphylococcal activity of zederone, isolated from the ethanolic extract of Z. zerumbet (L.) Smith against a series of multi-drug resistant (MDR) and methicillin resistant Staphylococcus aureus strains: SA1199B, ATCC25923, XU212, RN4220 and EMRSA15 [25] . "
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    • "The summary of plants containing pinocembrin, parts used, and biological/pharmacological activities is shown in Table 1. As shown in Figure 1, accumulated data indicate that pinocembrin was isolated from many plant species such as Alpinia mutica [40] [41], Litchi chinensis [42], Lippia graveolens [43], Lippia origanoides [44] [45], Dalea elegans [46], Oxytropis falcate [47] [48], Glycyrrhiza glabra L. [49] [50], Sparattosperma leucanthum [51], Cleome droserifolia [52], Lychnophora markgravii [53], Helichrysum gymnocomum [54], Syzygium samarangense [55], Centaurea eryngioides [56], Cistus incanus [27], Turnera diffusa [57], and Eriodictyon californicum [58]. Apart from natural sources, it has been noted that pinocembrin can be biosynthesized. "
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    ABSTRACT: Pinocembrin (5,7-dihydroxyflavanone) is one of the primary flavonoids isolated from the variety of plants, mainly from Pinus heartwood, Eucalyptus, Populus, Euphorbia, and Sparattosperma leucanthum, in the diverse flora and purified by various chromatographic techniques. Pinocembrin is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. In addition, pinocembrin can be used as neuroprotective against cerebral ischemic injury with a wide therapeutic time window, which may be attributed to its antiexcitotoxic effects. Pinocembrin exhibits pharmacological effects on almost all systems, and our aim is to review the pharmacological and therapeutic applications of pinocembrin with specific emphasis on mechanisms of actions. The design of new drugs based on the pharmacological effects of pinocembrin could be beneficial. This review suggests that pinocembrin is a potentially promising pharmacological candidate, but additional studies and clinical trials are required to determine its specific intracellular sites of action and derivative targets in order to fully understand the mechanism of its anti-inflammatory, anticancer, and apoptotic effects to further validate its medical applications.
    08/2013; 2013(6):379850. DOI:10.1155/2013/379850
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