Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation

Department of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Phytomedicine: international journal of phytotherapy and phytopharmacology (Impact Factor: 3.13). 05/2008; 15(4):306-9. DOI: 10.1016/j.phymed.2007.08.002
Source: PubMed


Twelve compounds isolated from Alpinia mutica Roxb., Kaempferia rotunda Linn., Curcuma xanthorhiza Roxb., Curcuma aromatica Valeton and Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from A. mutica and 3-deacetylcrotepoxide from K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC(50) values of less than 84 microM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC(50) values of 37.5, 60.9 and 45.7 microM, respectively.

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    • "Since a long time ago, tuberous rhizomes of Kaempferia rotunda L.. have been used as traditional medicine for a wide spectrum of diseases such as ulcer, gastrointestinal disorders etc. Many phytochemicals have been isolated from this rhizome with different bioactivities (Mohanty et al., 2008; Kupchan et al., 1969; Pai et al., 1970; Sirat et al., 2001; Jantan et al., 2008). A 29.0±1.0 "
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    ABSTRACT: Lectins are a group of carbohydrate-binding proteins of non-immune origin found in a diversity of organisms, plants, animals, fungi, bacteria and virus with potent biological activity. The present chapter is an attempt to represent a multidisciplinary study on this lectins isolated from medicinal plants like Nymphaea nouchali, Kaempferia rotunda, Kaempferia parviflora, Alisma orientale, Pinellia ternate and Phthirusa pyrifolia covering their purification process, information on hemagglutination activities and inhibition by sugars, as well as variation of stability with the change of temperature, pH and in presence of denaturants. Along with the toxicity of Kaempferia rotunda lectin and Nymphaea nouchali lectin against the brine shrimp nauplii, antibacterial activities of Kaempferia rotunda lectin, Nymphaea nouchali lectin, Eugenia uniflora L seeds lectin and Phthirusa pyrifolia leaf lectin, antiproliferative activities of Alisma orientale lectin, Pinellia ternate lectin, Kaempferia rotunda lectin, Nymphaea nouchali lectin and Pinellia ternate agglutinin against a number of cancer cell lines are described in brief.
    Recent Progress in Medicinal Plants, Edited by J.N. Govil, 12/2014: chapter Nutraceuticals and Functional Foods Volume 42, Chapter 18: pages 339-356; Studium Press LLC, Houston-Texas, USA., ISBN: 1-626990-79-4
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    • "Presently, rhizome's extract has been extensively studied for its effectiveness in a broad range of biological activities including antimicrobial [16], antipyretic [17], antispasmodic and anticonvulsant [3], antiulcer [18], antioxidant [19], antidiabetic [20], antitumor [21], anticancer [22, 23], anti-inflammatory [24, 25], antinociceptive and analgesic [26, 27], antiallergenic [28], antiangiogenic [29], antidipogenetic [30], antiplatelet aggregation and anticoagulant [31], and hepatoprotective effects [32]. Other studies have shown that consuming the rhizome also exhibits hypolipidemic effect by reducing intestinal cholesterol absorption, which makes it useful for treating heart diseases [33, 34]. "
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    ABSTRACT: Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review of assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutica effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in treatment of malignancies using ZER.
    BioMed Research International 06/2014; 2014(920742):20 pages. DOI:10.1155/2014/920742 · 1.58 Impact Factor
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    • "Zerumbone has been demonstrated to possess in vivo antinociceptive [20] and anti-inflammatory [21] [22] [23] activities. While in the in vitro studies, zerumbone has been reported to exhibit antiproliferative [20] and antiplatelet aggregation [24] activities. In our laboratory we have also found the antistaphylococcal activity of zederone, isolated from the ethanolic extract of Z. zerumbet (L.) Smith against a series of multi-drug resistant (MDR) and methicillin resistant Staphylococcus aureus strains: SA1199B, ATCC25923, XU212, RN4220 and EMRSA15 [25] . "

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