Tioman Virus, a Paramyxovirus of Bat Origin, Causes Mild Disease in Pigs and Has a Predilection for Lymphoid Tissues

Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Journal of Virology (Impact Factor: 4.44). 02/2008; 82(1):565-8. DOI: 10.1128/JVI.01660-07
Source: PubMed


Disease manifestation, pathology, and tissue tropism following infection with Tioman virus (TioPV), a newly isolated, bat-derived paramyxovirus, was investigated in subcutaneously (n = 12) and oronasally (n = 4) inoculated pigs. Pigs were either asymptomatic or developed pyrexia, but all of the animals produced neutralizing antibodies. The virus (viral antigen and/or genome) was detected in lymphocytes of the thymus, tonsils, spleen, lymph nodes and Peyer's patches (ileum), tonsillar epithelium, and thymic epithelioreticular cells. Virus was isolated from oral swabs but not from urine. Our findings suggest that the pig could act as an intermediate or amplifying host for TioPV and that oral secretion is a possible means of viral transmission.

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Available from: Meng Yu, Oct 07, 2015
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    • "In light of the evidence that the paramyxoviruses MenPV and NiV originate from bats and involve pigs as intermediate or amplifying hosts (Kirkland et al., 2002), a study to determine the susceptibility of pigs to TioPV infection was undertaken (Yaiw et al., 2008a). TioPV was found to be capable of infecting and replicating in pigs and the main cellular targets were lymphocytes, thymic epithelioreticular cells, and the tonsillar "
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