Telomere length predicts survival independent of genetic influences. Aging Cell 6:769-774

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Aging cell (Impact Factor: 6.34). 01/2008; 6(6):769-74. DOI: 10.1111/j.1474-9726.2007.00340.x
Source: PubMed


Telomeres prevent the loss of coding genetic material during chromosomal replication. Previous research suggests that shorter telomere length may be associated with lower survival. Because genetic factors are important for individual differences in both telomere length and mortality, this association could reflect genetic or environmental pleiotropy rather than a direct biological effect of telomeres. We demonstrate through within-pair analyses of Swedish twins that telomere length at advanced age is a biomarker that predicts survival beyond the impact of early familial environment and genetic factors in common with telomere length and mortality. Twins with the shortest telomeres had a three times greater risk of death during the follow-up period than their co-twins with the longest telomere measurements [hazard ratio (RR) = 2.8, 95% confidence interval 1.1-7.3, P = 0.03].

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    • "go progressive shortening after each round of division in most somatic cells , and when telomeres reach a critical minimum length , cells stop dividing or undergo apoptosis . The lengths of telomeres in leukocytes is positively correlated with lifespan ; therefore , these telomeres have been proposed as a potential biomarker of biological ageing ( Bakaysa et al . , 2007 ; Fitzpatrick et al . , 2007 ; Kimura et al . , 2008b ; Oeseburg et al . , 2010 ) . In contrast , telomeres of sperm are length ened by the action of telomerase , which is expressed at high levels in spermatogonia , resulting in an increase in telo - mere length with age in human sperm ( Kimura et al . , 2008a ) ."
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    ABSTRACT: The ends of eukaryotic chromosomes contain specialized chromatin structures called telomeres, the length of which plays a key role in early human embryonic development. Although the effect of sperm preparation techniques on major sperm characteristics, such as concentration, motility and morphology have been previously documented, the possible status of telomere length and its relation with sperm preparation techniques is not well-known for humans. The aim of this study was to investigate the role of density gradient centrifugation in the selection of spermatozoa with longer telomeres for use in assisted reproduction techniques in 105 samples before and after sperm processing. After density gradient centrifugation, the average telomere length of the sperm was significantly longer (6.51 ± 2.54 versus 5.16 ± 2.29, P < 0.01), the average motile sperm rate was significantly higher (77.9 ± 11.8 versus 44.6 ± 11.2, P < 0.01), but average DNA fragmentation rate was significantly lower (11.1 ± 5.9 versus 25.9 ± 12.9, P < 0.01) compared with raw semen. Additionally, telomere length was positively correlated with semen sperm count (rs = 0.58; P < 0.01). In conclusion, density gradient centrifugation is a useful technique for selection of sperm with longer telomeres. Copyright © 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
    Reproductive biomedicine online 03/2015; 31(1). DOI:10.1016/j.rbmo.2015.02.016 · 3.02 Impact Factor
    • "independent of chronological age (Bakaysa et al., 2007; Brouilette et al., 2007), although others, particularly when examining LTL in older populations or with limited follow-up time, have not (Mather et al., 2010, 2011). A recent review identified 124 cross-sectional and 5 longitudinal studies of LTL that examined associations with age, finding the relationship was very consistent, but that variations of the rate of decrease are still unclear, in large part due to lack of longitudinal studies (Muezzinler et al., 2013). "
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    ABSTRACT: Peripheral blood leukocyte telomere length (LTL) is increasingly being used as a biomarker of aging, but its natural variation in human populations is not well understood. Several other biomarkers show seasonal variation, as do several determinants of LTL. We examined whether there was monthly variation in LTL in Costa Rica, a country with strong seasonal differences in precipitation and infection. We examined a longitudinal population-based cohort of 581 Costa Rican adults age 60 and above, from which blood samples were drawn between October 2006 and July 2008. LTL was assayed from these samples using the quantitative PCR method. Multivariate regression models were used to examine correlations between month of blood draw and LTL. Telomere length from peripheral blood leukocytes varied by as much as 200 base pairs depending on month of blood draw, and this difference is not likely to be due to random variation. A moderate proportion of this association is statistically accounted for by month and region specific average rainfall. We found shorter telomere length associated with greater rainfall. There are two possible explanations of our findings. First, there could be relatively rapid month-to-month changes in LTL. This conclusion would have implications for understanding the natural population dynamics of telomere length. Second, there could be seasonal differences in constituent cell populations. This conclusion would suggest that future studies of LTL use methods to account for the potential impact of constituent cell type. Am. J. Hum. Biol., 2014. © 2014 Wiley Periodicals, Inc.
    American Journal of Human Biology 05/2014; 26(3). DOI:10.1002/ajhb.22529 · 1.70 Impact Factor
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    • "(Bakaysa et al., 2007) "
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