Article

Potent inhibition of genital herpesvirus infection in goats by cidofovir.

Department of Animal Health and Well-being, Faculty of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.
Antiviral therapy (impact factor: 3.16). 02/2007; 12(6):977-9. pp.977-9
Source: PubMed

ABSTRACT Like human herpesvirus 2 (HHV-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs.
The antiviral activity of cidofovir was assessed in goats infected experimentally, using various therapeutic protocols.
Topic administration of cidofovir 1% cream prevented the onset of virus-induced genital lesions and drastically reduced virus shedding.
Cidofovir appears to be a very efficient drug for the prevention of genital lesions caused by an alphaherpesvirus.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

alphaherpesvirus
 
anti-herpetic drugs
 
antiviral activity
 
caprine herpesvirus 1
 
Cidofovir
 
cidofovir 1% cream
 
efficient drug
 
genital lesions
 
HHV-2
 
human herpesvirus 2
 
humans
 
Topic administration
 
unique model
 
various therapeutic protocols
 
virus-induced genital lesions