Potent inhibition of genital herpesvirus infection in goats by cidofovir.
ABSTRACT Like human herpesvirus 2 (HHV-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs.
The antiviral activity of cidofovir was assessed in goats infected experimentally, using various therapeutic protocols.
Topic administration of cidofovir 1% cream prevented the onset of virus-induced genital lesions and drastically reduced virus shedding.
Cidofovir appears to be a very efficient drug for the prevention of genital lesions caused by an alphaherpesvirus.