127 Volume 49, Number 2
Peculiarities of Coronary Artery Atherosclerosis
in Male Patients of Yakut Nationality with
Ischemic Heart Disease
A.N. Romanova, M.I. Voevoda
Yakut Scientific Centre of RAMS and Government of the Sakha Republic (Yakutia),
Yakutsk; Institute for Internal Medicine SB RAMS, Novosibirsk, Russia
Institute of Health of the Republic of Sakha (Yakutia) Academy of Sciences, Yakutsk, Russia
atherosclerosis according to data of selective
coronaroangiography (SCAG) in male patients of Yakut
nationality with ischemic heart disease (IHD). Materials and
methods: 148 Yakut and Russian males with IHD have been
observed in the research. They were inpatients of a cardiology
unit, Republican Hospital No.1—National Centre of Medicine,
Yakutsk for 2004-2006. Patients were divided into two clinical
Groups: 1 – Yakut males with IHD (n=74, mean age 53.8±09 years);
2 – Russian males with IHD (n=74, mean age 52.9±0.9 years). The
study was based on anamnesis data, clinical investigation and
included data of twofold measure of blood pressure,
anthropometry, electrocardiography, echocardiography, SCAG,
determination of levels of total cholesterol (TCh) and cholesterol
of high- (HDL) and low-density (LDL) lipoproteins and
triglycerides (TG). Results: The Yakuts have more frequently 1-
vascular lesion of CA according to SCAG. The frequency of lesion
left anterior descending artery (LAD) and right coronary artery
(RCA) is equal in both groups, at the same time occlusion of LAD
more frequently occurred in Group 1 (61% against 42%), and
occlusion of RCA more often occurred in Group 2 (46% against
21%). Conclusion: Atherosclerosis of CA among Yakut patients
with IHD is less expressed. Risk factors (RF) among Yakuts with
IHD, like smoking, overweight, lipid disorders occurred less
frequently than in group of non-Natives.
Key words: atherosclerosis of coronary artery, selective
coronaroangiography, risk factor.
Purpose: To study the peculiarities of coronary artery
In Yakutia the prevalence of cardiovascular diseases (CVD)
increases annually. Based on statistical data, nearly one of
two cases results from circulation system disorders (41.5%),
of them IHD and insults amount to 46.9 and 37.6%,
respectively. The high morbidity and mortality rate of
indigenous population of Yakutia due to myocardial infarction
(MI) and insult is taken into account, this pathology tending
to involve younger people as well. For nearest 10 years the
epidemiological situation regarding CVD and IHD lethality
appears to be worsened among male population of Yakutia.
According to research data on studying regional
peculiarities of the RF prevalence, the RF profile is justifiably
favorable in males of indigenous nationality as compared with
the new-coming population[6, 7, 8, 9, 10, 11, 12].
According to the consideration of epidemiologic
morphometrical studies, the coronary atherosclerosis
progression has been observed among the Natives, whereas
on the basis of previous research data the disease process
was of a lower severity and prevalence when comparing with
the non-Natives (European) population[1, 3].
To study peculiarities of coronary artery atherosclerosis
according to SCAG in males of Yakut nationality with IHD.
MATERIALS AND METHODS
148 Yakut and Russian males with IHD have been observed
in the research. They were inpatients of the cardiology unit,
Republican Hospital No.1—National Centre of Medicine,
Yakutsk for 2004-2006. Patients were divided into two clinical
Groups: 1 – Yakut males with IHD (n=74, mean age 53.8±0.9
years); 2 – Russian males with IHD (n=74, mean age 52.9±0.9
SCAG was conducted by means of the angiographic set
«Axiom. Artis BA» (Siemens) by generally accepted methods.
The CA stenosis degree was detected automatically in
accordance with the classification worked out by the American
College of Cardiology and American Heart Association.
Blood for chemical analysis was taken by venepunction
in a sitting position after 12-hour food abstinence. Having
been centrifuged, the serum was stored at a low temperature
(-70º) until the analysis being taken. The serum lipid spectrum
was determined by a standard fermental analysis by means
of the commersials sets «Biocon» (Germany) on the
autoanalyser «Labsystem» (Finland) in the clinical
biochemistry laboratory, SRI on therapy SB RAMS.
Hypercholesterolemia (HC) was accepted as the level of TCh
>5.0 mmol/l (190 mg/dl), higher level of LDL >3 mmol/l (115
mg/dl), hypertriglyceridemia was for the level of TG >1.7
mmol/l (150 mg/dl), hypo-HDL - level HDL <1.0 mmol/l (40
The statistical processing of data been conducted with
the program SPSS (version 11.5).
In Group 1 a number of CA 1-vascular lesions (49%) prevailed
over 2-vascular (19%) and multiple vascular (32%) ones versus
in Group 2 the rate of CA multiple lesions was significantly
higher (53%) than 1-vascular (17%) and 2-vascular (30%)
Alaska Medicine, Supplement128
lesions. Our findings confirm the morphometrical research
data obtained by Argunov V.A., Voronova O.V.[3,4].
In Group 1 balanced (43%) and right-coronary (41%) types
prevailed over a left-coronary type, while in Group 2 left- (37%)
and right-(35%) coronary types have an advantage over the
balanced type (28%). When comparing the CA sickness rate
of Groups 1 and 2, we found that LAD (39 and 36%) in the
disease process more frequently, followed by RCA (29 and
30%), circumflex artery (CA) (18 and 21%), an obtuse margin
artery (OMA) (4 and 10%), diagonal artery (DA) (5 and 1%)
and left main trunk (LMT) (5 and 2% accordingly) (Fig. 1).
In Group 1 the occlusion of LAD rate numbered 61percent,
RCA – 21%, CA – 12%, OMA – 3%, occlusion of LMT – 3%
cases (Fig. 2). In Group 2 the situation as follows: the occlusion
of LAD - 42% cases, RCA - 46%, CA - 8%, OMA - 4%, stenosis
of LMT- 4% (Fig. 3).
The patients of both Groups suffered from arterial
hypertension (AH) of 84 and 76%, type 2 diabetes mellitus
(DM2) - 8 and 24%, smoking - 39 and 57%, overweight - 81
and 82% (obesity was noted more often among males of Group
2 (45% versus 30%)), MI burdened inheritance - 5 and 18%,
ADEC - 12 and 4%, respectively (Table 1).
A higher rate of dislipoproteidemias (HC, HTG, hypo-
HDL) was noted in the patients of Group 2 as compared with
the subjects of Group 1. The HC prevalence rate in Groups 1
and 2 amounted for 24 and 31%, HTG – 37 and 41%,
respectively. Hypo-HDL was observed more frequently among
the patients of Group 2 - at 59% cases.
In Group 2 the TCh mean levels were as follows: 5.03±0.23
against 4.65±0.19 mmol/l. TGs (2.3±0.18 against 1.91±0.14
mmol/l) were at a higher level, HDL (0.85±0.04 against
1.01±0.58 mmol/l) were lower as compared with the patients
of Group 1. These data confirm to research findings obtained
by Klimova T.M., Popova E.K., and Shadrina O.V..
Atherosclerosis of CA among Yakut patients with IHD is
expressed less. The Yakuts more frequently have 1-vascular
lesion (49 against 17%). The frequency of lesion LAD and
RCA is equal in both groups, at the same time occlusion of
LAD more frequently occurred in Group 1 (61 against 42%),
and occlusion of RCA more often occurred in Group 2 (46
against 21%). RF among Yakut patients, like smoking,
overweight, lipid disorders, occurred less frequently than in
group of non-Natives.
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development and their pathomorphosis among Native and
non-natives population of the North: diss. abstract ... Doctor
of medical sciences – Moscow, 1990. – 8 p.
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peculiarities of atherosclerosis in males of Yakutsk // Ter.
archives. – 2001. - No. 1. - P. 12-17.
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in aorta and coronary artery among children and juveniles
of indigenous and new-coming population of Yakutia. Their
significance in atherosclerosis onset: diss. Abstract ... Doctor
of medical sciences – M., 1996. – 29 p.
Voronova O.V. Pathomorphological monitoring of aortal and
coronary artery atherosclerosis among indigenous and new
arrived male population of Yakutsk city: diss. abstract ...
Doctor of medical sciences. – M., 2005. - 23 p.
Diagnostics and correction of lipid exchange disorders with
the purpose of atherosclerosis prophylactics and treatment:
Russian recommendations // Appendix “Cardiovascular
therapy and prophylactics”. – 2004. No. 2. – P. 35.
Klimova T.M. Dynamics of AH prevalence and its linkage
with risk factors among male population of Yakutsk: diss.
abstract ... Candidate of medical sciences.-Novosibirsk, 2001.
- 22 p.
Kornilieva I.V. Prevalence of CVD risk factors among adult
population of the Republic of Sakha (Yakutia) and their
medical and social significance: diss. abstract ... Candidate of
medical sciences. - M., 2004. – 26 p.
Osipova O.N. IHD prevalence rate and risk factors among
autodrivers of Yakutsk city: diss. abstract ... Candidate of
medical sciences. - M., 2000. – 20 p.
Petrova I.R. Clinical and genetic peculiarities of hypertonic
disease in Yakut population: diss. abstract ... Candidate of
medical sciences. - M., 2004. – 22 p.
10. Popova E.K. Peculiarities of blood serum lipid and
apolipoprotein profile in patients with IHD a condition of
the Far North: diss. abstract ... Candidate of medical sciences.
– Yakutsk, 2004. – 24 p.
11. Romanova T.A. IHD risk factors and its severity in population
of Yakutia: linkage with gene-candidates polymorphism: diss.
abstract ... Candidate of medical sciences.-M.,-2003. – 21 p.
12. Shadrina O.V. Peculiarities of dislipoproteins epidemiology
and IHD other risk factors among male population of Yakutsk:
diss. Abstract ... Candidate of medical sciences. - Novosibirsk,
2002. – 21 p.
13. European guidelines in cardiovascular disease prevention in
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Yakut Scientific Centre of Russian Academy of Medical
Sciences and Government of Sakha Republic (Yakutia)
4, Sergelyakhskoe shosse
Sakha Republic (Yakutia), Russia
129 Volume 49, Number 2
Group 1 Group 2
LMT LAD CA DAOMAPCA
Figure 1. The rate of coronary artery lesion in Groups 1 and 2
Figure 2. The coronary artery stenosis degree in Group 1
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LMT LAD CA DAOMA PCA
Figure 3. The coronary artery stenosis degree in Group 2
Frequency of the main risk factors in patients of Groups 1 and 2