Masticatory dysfunction is associated with osteoporosis in older men
ABSTRACT Thirty per cent of hip fractures occur in men. Nevertheless, the determinants of osteoporosis in men are unclear. Masticatory dysfunction is associated with malnutrition, and might represent an emergent cause of osteoporosis. The aim of this study was to assess the association of bone mineral density and self-assessed masticatory dysfunction in a general older population.
We assessed the association of masticatory dysfunction with standard parameters of bone mineral density (T-score, Z-score and the stiffness index) in all 310 subjects aged 75+ living in Tuscania (Italy).
Among men, self-assessed masticatory dysfunction was associated with T-score [beta=0.86, confidence intervals (CI)=0.15-1.57; p=0.019], Z-score (beta=0.86, CI=0.16-1.56; p=0.017) and the stiffness index (beta=9.12, CI=0.47-17.77; p=0.039) in linear regression modeling, after adjusting. No significant associations were observed in women.
Masticatory dysfunction is independently associated with osteoporosis in elderly men. Evaluation of masticatory function should enter the routine assessment of older men with osteoporosis.
SourceAvailable from: Francesco Franceschi[Show abstract] [Hide abstract]
ABSTRACT: Background Malnutrition has been found in up to 24% of patients with Parkinson's disease; dopaminergic drugs might impair nutritional status. We evaluated the association of nutritional status with the use of dopaminergic agents.Methods We analyzed data from 75 elderly patients with Parkinson's disease attending a geriatric day hospital. Nutritional status was assessed by the Mini Nutritional Assessment (MNA). Dopaminergic drugs were normalized for weight.ResultsIn linear regression, total levodopa (l-dopa) equivalent daily dose (LEDD) was associated with worse MNA (B = −0.14, 95% CI = −0.26-−0.02; P = 0.019). This association remained significant only for l-dopa (B = −0.19, 95% CI = −0.32-−0.52; P = 0.007), but not dopaminergic agent dosages. Increasing l-dopa dosages were associated with increasing probability of risk of malnutrition (P for trend = 0.049).Conclusions In our population, LEDD was associated with worse nutritional status and risk of malnutrition; this association was limited to use of l-dopa. © 2014 International Parkinson and Movement Disorder SocietyMovement Disorders 10/2014; 29(12). DOI:10.1002/mds.25991 · 5.63 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Depression is increasingly recognized in older populations and associated with undernutrition, disability, and increased mortality. Chewing problems (CPs) share with depression these associations. The aim of the study was to evaluate the association, if any, between CPs and depression in older subjects. We assessed 927 participants aged 65 years and older, derived from the 'InCHIANTI' study. Mood was evaluated using the CES-D scale and defined depressed by a CES-D score ≥20. CPs were self-reported. Logistic regression was performed to assess the adjusted association between depression and CPs. The adjusted model was analyzed after stratifying for use of complete, partial dentures and edentulism. Chewing problems were reported by 293/927 (31.6%) participants. Depression was present in 188/927(20.3%) participants. In multivariable logistic regression, CPs were associated with depression (OR = 1.81, 95% CI = 1.26-2.58; p = 0.001). No significant association was found among subjects who used complete dentures (OR = 1.12, 95% CI = 0.80-1.58, p = 0.515). Up to 27.8% of prevalent depression might be attributed to CPs. Chewing problems are associated with depression in elderly population. Use of complete dentures hinder this association. Older depressed subjects should be screened for the presence of CPs; further studies are needed to evaluate the impact of early detection and correction of CPs on the development of depression. Copyright © 2013 John Wiley & Sons, Ltd.International Journal of Geriatric Psychiatry 03/2014; 29(3). DOI:10.1002/gps.3995 · 3.09 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: To compare masticatory performance, masticatory efficiency and residual ridge resorption (RRR) in osteoporotic and non-osteoporotic edentulous subjects after rehabilitation with complete dentures. Thirty subjects fulfilling the inclusion criteria were enrolled from the patients visiting the Department of Prosthodontics for complete denture fabrication. Two groups consisting of control subjects (group I; N = 15) and osteoporotic subjects (group II; N = 15) were formed. Complete dentures satisfying certain criteria were fabricated for both groups. Masticatory performance and efficiency were measured 6 months after denture insertion. Areal measurements were taken on lateral cephalograms before and 6 months after denture fabrication. The data were then computed to analyse differences between groups I and II using SPSS statistical software version 15.0. Six months after denture fabrication, the masticatory performance and efficiency were significantly higher (p < 0.001) for group I, with a significant decrease in maxillary and mandibular sagittal area seen in both groups. The rate of bone loss was more in group II compared with group I. Greater masticatory function was demonstrated by the non-osteoporotic group, and the rate of RRR was more in the osteoporotic group compared with the normal group. In this pilot study, osteoporosis leads to greater RRR, decreased masticatory performance and efficiency in edentulous subjects 6 months after denture insertion. Screening for osteoporosis is suggested as a routine procedure for all edentulous subjects undergoing rehabilitation. Recall check-ups for osteoporotic patients should be more frequent, and these patients may require more frequent denture remakes.Gerodontology 01/2012; 29(2):e1059-66. DOI:10.1111/j.1741-2358.2011.00610.x · 0.81 Impact Factor