Article

Perinatal and postnatal exposure to bisphenol A increase adipose tissue mass and serum cholesterol level in mice

Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Ehime, Japan.
Journal of atherosclerosis and thrombosis (Impact Factor: 2.77). 11/2007; 14(5):245-52. DOI: 10.5551/jat.E486
Source: PubMed

ABSTRACT To investigate whether the perinatal and postnatal exposure of mice to bisphenol A (BPA) caused the development of obesity and/or hyperlipidemia.
Pregnant mice were exposed to BPA in drinking water at concentrations of either 1 microg/mL (LD group) or 10 microg/mL (HD group) from gestation day 10 and throughout the lactating period. After weaning, the pups were allowed free access to drinking water containing the appropriate concentrations of BPA. The body weight, adipose tissue weight, and serum lipid levels were measured in the offspring at postnatal day 31.
In females, the mean body weight increased by 13% in the LD group (p<0.05) and 11% in the HD group (p<0.05) compared with the control group. The mean adipose tissue weight increased by 132% in the LD group (p<0.01). The mean total cholesterol level increased by 33% in the LD group (p<0.01) and 17% in the HD group (p<0.05). In males, the mean body weight and mean adipose tissue weight increased by 22% (p<0.01) and 59% (p<0.01), respectively, in the HD group compared with the control group. The mean triacylglycerol level increased by 34% in the LD group (p<0.05).
The continuous exposure of mice to BPA during the perinatal and postnatal periods caused the development of obesity and hyperlipidemia.

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    Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology 02/2015; 184. DOI:10.1016/j.cbpb.2015.02.001 · 1.90 Impact Factor
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    • "Most people worldwide have detectable levels of BPA in their blood or urine indicating a ubiquitous exposure (Vandenberg et al., 2007; Olsen et al., 2012). Furthermore, BPA has been shown to induce obesity in rodents in experimental settings by different groups (Miyawaki et al., 2007; Somm et al., 2009), and in humans. Lang et al. and Shankar et al. found urinary BPA to be related to obesity measured by BMI in the NHANES study performed in adults (Lang et al., 2008; Shankar et al., 2012). "
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