Nucifora PG, Verma R, Lee SK, Melhem ER. Diffusion-tensor MR imaging and tractography: exploring brain microstructure and connectivity

Yonsei University, Sŏul, Seoul, South Korea
Radiology (Impact Factor: 6.21). 12/2007; 245(2):367-84. DOI: 10.1148/radiol.2452060445
Source: PubMed

ABSTRACT Diffusion magnetic resonance (MR) imaging is evolving into a potent tool in the examination of the central nervous system. Although it is often used for the detection of acute ischemia, evaluation of directionality in a diffusion measurement can be useful in white matter, which demonstrates strong diffusion anisotropy. Techniques such as diffusion-tensor imaging offer a glimpse into brain microstructure at a scale that is not easily accessible with other modalities, in some cases improving the detection and characterization of white matter abnormalities. Diffusion MR tractography offers an overall view of brain anatomy, including the degree of connectivity between different regions of the brain. However, optimal utilization of the wide range of data provided with directional diffusion MR measurements requires careful attention to acquisition and postprocessing. This article will review the principles of diffusion contrast and anisotropy, as well as clinical applications in psychiatric, developmental, neurodegenerative, neoplastic, demyelinating, and other types of disease.

  • Source
    • "The first magnetic resonance sequence able to measure diffusion coefficient in structures was developed in the early 80's (Wesbey et al., 1984), paving the way for a new, well-established imaging contrast for in vivo quantification of molecular diffusivity. Although a variety of sequences are now used to acquire diffusion weighted (DW) images, all DW sequences include two equal and opposing motion-probing gradients (Nucifor et al., 2007). The acquired signal from a voxel will exponentially decay as function of a parameter b which determines the strength and duration of the diffusion gradients and essentially represents the measurement's sensitivity to water diffusion . "
    [Show abstract] [Hide abstract]
    ABSTRACT: BACKGROUND: Progress in neuroimaging has yielded new powerful tools which, potentially, can be applied to clinical populations, improve the diagnosis of neurological disorders and predict outcome. At present, the diagnosis of consciousness disorders is limited to subjective assessment and objective measurements of behavior, with an emerging role for neuroimaging techniques. In this review we focus on white matter alterations measured using Diffusion Tensor Imaging on patients with consciousness disorders, examining the most common diffusion imaging acquisition protocols and considering the main issues related to diffusion imaging analyses. We conclude by considering some of the remaining challenges to overcome, the existing knowledge gaps and the potential role of neuroimaging in understanding the pathogenesis and clinical features of disorders of consciousness.
    Frontiers in Human Neuroscience 01/2015; 8. DOI:10.3389/fnhum.2014.01028 · 2.90 Impact Factor
  • Source
    • "These features have been attributed to the disruption of the underlying structures of neural networks [Ellison-Wright and Bullmore , 2009; Kubicki et al., 2007]. Diffusion MRI is a technique that is capable of detecting the microstructural integrities of the axonal fibers of the white matter [Basser et al., 2000; Nucifora et al., 2007] and has revealed disruptions of these networks in vivo [Kanaan et al., 2005]. Numerous diffusion MRI studies have reported abnormal white matter regions in patients with schizophrenia and also in first-episode, drug-na€ ıve, and high-risk patients [Lee et al., 2013; Peters et al., 2008; Samartzis et al., 2014]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Trait markers of schizophrenia aid the dissection of the heterogeneous phenotypes into distinct subtypes and facilitate the genetic underpinning of the disease. The microstructural integrity of the white matter tracts could serve as a trait marker of schizophrenia, and tractography-based analysis (TBA) is the current method of choice. Manual tractography is time-consuming and limits the analysis to preselected fiber tracts. Here, we sought to identify a trait marker of schizophrenia from among 74 fiber tracts across the whole brain using a novel automatic TBA method. Thirty-one patients with schizophrenia, 31 unaffected siblings and 31 healthy controls were recruited to undergo diffusion spectrum magnetic resonance imaging at 3T. Generalized fractional anisotropy (GFA), an index reflecting tract integrity, was computed for each tract and compared among the three groups. Ten tracts were found to exhibit significant differences between the groups with a linear, stepwise order from controls to siblings to patients; they included the right arcuate fasciculus, bilateral fornices, bilateral auditory tracts, left optic radiation, the genu of the corpus callosum, and the corpus callosum to the bilateral dorsolateral prefrontal cortices, bilateral temporal poles, and bilateral hippocampi. Posthoc between-group analyses revealed that the GFA of the right arcuate fasciculus was significantly decreased in both the patients and unaffected siblings compared to the controls. Furthermore, the GFA of the right arcuate fasciculus exhibited a trend toward positive symptom scores. In conclusion, the right arcuate fasciculus may be a candidate trait marker and deserves further study to verify any genetic association. Hum Brain Mapp, 2014. © 2014 Wiley Periodicals, Inc.
    Human Brain Mapping 11/2014; 36(3). DOI:10.1002/hbm.22686 · 6.92 Impact Factor
  • Source
    • "ivity . Of the extensive cellular responses produced by ischemia , those considered most likely to affect the diffusion properties of water are those that in - volve morphological tissue changes such as necrosis , astrogliosis , loss of myelin , loss of axonal neurofilaments or cellular inflammation ( i . e . microglial / macrophage activation ) ( Nucifora et al . , 2007 ; Zhang et al . , 2012 ) . Our group and others have shown that corticospinal tract DTI al - terations are strongly correlated with motor outcome in children with perinatal stroke ( Hodge , 2013 ; Roze et al . , 2012 ; van der Aa et al . , 2011 ) . However the progression of DTI changes and whether there are differences between the evol"
    [Show abstract] [Hide abstract]
    ABSTRACT: Ischemically damaged brain can be accompanied by secondary degeneration of associated axonal connections e.g. Wallerian degeneration. Diffusion tensor imaging (DTI) is widely used to investigate axonal injury but the cellular correlates of many of the degenerative changes remain speculative. We investigated the relationship of DTI of directly damaged cerebral cortex and secondary axonal degeneration in the cerebral peduncle with cellular alterations in pan-axonal neurofilament staining, myelination, reactive astrocytes, activation of microglia/macrophages and neuronal cell death. DTI measures (axial, radial and mean diffusivity, and fractional anisotropy (FA)) were acquired at hyperacute (3 h), acute (1 and 2 d) and chronic (1 and 4 week) times after transient cerebral hypoxia with unilateral ischemia in neonatal rats. The tissue pathology underlying ischemic and degenerative responses had a complex relationship with DTI parameters. DTI changes at hyperacute and subacute times were smaller in magnitude and tended to be transient and/or delayed in cerebral peduncle compared to cerebral cortex. In cerebral peduncle by 1 d post-insult, there were reductions in neurofilament staining corresponding with decreases in parallel diffusivity which were more sensitive than mean diffusivity in detecting axonal changes. Ipsilesional reductions in FA within cerebral peduncle were robust in detecting both early and chronic degenerative responses. At one or four weeks post-insult, radial diffusivity was increased ipsilaterally in the cerebral peduncle corresponding to pathological evidence of a lack of ontogenic myelination in this region. The detailed differences in progression and magnitude of DTI and histological changes reported provide a reference for identifying the potential contribution of various cellular responses to FA, and, parallel, radial, and mean diffusivity.
    Clinical neuroimaging 08/2014; 6. DOI:10.1016/j.nicl.2014.08.003 · 2.53 Impact Factor
Show more