Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation.

Laboratory of Protein Dynamics and Signaling, Building 560 Room 22-103, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, United States.
Seminars in Cell and Developmental Biology (Impact Factor: 5.97). 01/2008; 18(6):770-9. DOI: 10.1016/j.semcdb.2007.09.002
Source: PubMed

ABSTRACT Endoplasmic reticulum-associated degradation (ERAD) represents the primary means of quality control within the secretory pathway. Critical to this process are ubiquitin protein ligases (E3s) which, together with ubiquitin conjugating enzymes (E2s), mediate the ubiquitylation of proteins targeted for degradation from the ER. In this chapter we review our knowledge of both Saccharomyces cerevisiae and mammalian ERAD ubiquitin ligases. We focus on recent insights into these E3s, their associated proteins and potential mechanisms of action.

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