Community-acquired methicillin-resistant Staphylococcus aureus infection with fatal necrotizing pneumonia from lip abscess: a case report.

Department of Oral and Maxillofacial Surgery, University of Oklahoma Health Science Center, Oklahoma City, OK 73034, USA.
Journal of Oral and Maxillofacial Surgery (Impact Factor: 1.28). 12/2007; 65(11):2350-3. DOI: 10.1016/j.joms.2006.09.020
Source: PubMed
  • [Show abstract] [Hide abstract]
    ABSTRACT: Only recently necrotizing pneumonia was defined as a specific disease entity that is caused by a Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus strain and is frequently preceded by an influenza infection. Necrotizing pneumonia is characterized by a sudden onset and rapid worsening of symptoms, leukopenia, airway hemorrhages, severe respiratory failure and a high mortality rate. Despite clear epidemiological data, the function of PVL in necrotizing pneumonia has been controversially discussed due to conflicting results from different disease models. Furthermore, there are many proposed mechanisms how a viral infection could facilitate and interact with a bacterial superinfection. In this review, we summarize current data from 43 clinical cases and results from various infection models on necrotizing pneumonia. We discuss the contribution of S. aureus PVL and a preceding influenza infection and present a concept of the pathogenesis of necrotizing pneumonia.
    Expert Review of Anticancer Therapy 09/2013; · 3.22 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose The purpose of this paper was to undertake a systematic review of literature on methicillin-resistant Staphylococcus aureus infections in oral and maxillofacial online data-bases and discuss the Infectious Diseases Society of America (IDSA) guidelines and its applications in maxillofacial clinical practice. Materials and Methods The available literature in oral and maxillofacial online databases was searched. The only inclusion criterion was to review published reports, abstracts and retrospective studies with emphasis on the treatment of clinical cases with methicillin-resistant S. aureus infections. Clinical Practice Guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant S. aureus infections in adults and children was reviewed and included in the study. Results Out of 18 articles found with the search terms “Methicillin-resistant S. aureus” and “MRSA” in the online databases 12 articles met the inclusion criteria for this study. The relevant data was extracted and tabulated. Conclusions Conclusions were drawn and discussed based on the reviewed maxillofacial literature and the Guidelines by the IDSA.
    Journal of Maxillofacial and Oral Surgery 09/2013;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We evaluated the published data for the incidence, characteristics and outcomes of patients with community-acquired pneumonia (CAP) due to methicillin-resistant Staphylococcus aureus (MRSA). The estimated incidence of MRSA CAP is 0.51-0.64 cases per 100,000. We identified 74 articles reporting data on 114 patients. Influenza like symptoms was reported in 41% of patients. Pneumonia improved in 59 (54.1%) out of 109 patients; 49 (44.5%) out of 110 patients died. The duration of hospitalisation was 38.1+/-24.9 and 8.3+/-11.7 days, respectively. The duration of intensive care unit (ICU) stay was 18.9+/-13.6 and 6.8+/-9.7 days, respectively. 76 strains carried the Panton-Valentine leukocidin gene. The univariate analysis showed that multi-organ failure (p<0.001), leukopenia (p<0.001), admission to ICU (p<0.001), mechanical ventilation (p<0.001), use of aminoglycosides after culture results (p<0.001), shock (p = 0.001), acute respiratory distress syndrome (p = 0.001), influenza like symptoms (p = 0.008), disseminated intravascular coagulation (p = 0.042) and rash (p = 0.04) were the factors associated with death.
    European Respiratory Journal 06/2009; 34(5):1148-58. · 6.36 Impact Factor