Tethered cord syndrome: nationwide inpatient complications and outcomes.

Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Neurosurgical FOCUS (Impact Factor: 2.11). 02/2007; 23(2):E3. DOI: 10.3171/FOC-07/08/E3
Source: PubMed


Previous investigations of health outcome after spinal surgery for tethered cord syndrome (TCS) have been single-institution studies. The aim of this study was to report inpatient complications and outcomes on a nationwide level.
The Nationwide Inpatient Sample (NIS) was used to identify patients who underwent spinal surgery for TCS in the US between 1993 and 2002. Patients who had a primary diagnosis of TCS (ICD-9 742.59) and also underwent spinal laminectomies were included in this study. Multivariate analysis was performed to analyze the effects of patient and hospital characteristics on variables such as mortality rate, nonfatal complications, LOS, and adverse outcomes in general (defined as death or discharge to an institution rather than home).
The NIS sample included data on 9733 patients with TCS who underwent surgery. The means for mortality rate, complication rate, and LOS, respectively, were 0.0005%, 9.48%, and 5.6 days. Postoperative hemorrhages or hematomas (mean rate 2.3%) were the most common complications reported. Age and complications were the only significant predictors of adverse outcome on multivariate analysis. Patients older than 65 years had a threefold increase in risk of adverse outcome compared with patients 18 to 44 years of age. On average, one postoperative complication led to a 3-day increase in mean LOS and added more than $9000 to hospital charges.
This study provides a national perspective on inpatient complications and outcomes after spinal surgery for TCS in the United States. The authors have demonstrated the impact of age, complications, and medical comorbidities on the outcome of surgery for patients with this common disorder.

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    • "The tissue is typically obtained from tethered cord surgeries, and the donor age can vary from a few months postnatal to adulthood. The precise location of the tissue and the manner in which it is handled (including time to culture) also varies from operation to operation and naturally between clinical centers [39], [40]. Therefore, we sought to develop a rodent model for studying the FT that would permit the standardization of experiments, provide unlimited amounts of tissue, allow sampling at particular stages of the life cycle, and permit the use of transgenic animals. "
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