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Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling.

Evan W Miller, Christopher J Chang

Department of Chemistry, University of California, Berkeley, CA 94720, USA.

Journal Article: Current Opinion in Chemical Biology (impact factor: 8.3). 01/2008; 11(6):620-5. DOI: 10.1016/j.cbpa.2007.09.018

Abstract

Nitric oxide (NO) and hydrogen peroxide (H(2)O(2)) have emerged as essential small molecules for cellular signal transduction owing largely to their ability to mediate oxidative posttranslational modifications (PTMs). Inventing new ways to track these small, diffusible, and reactive species with spatial and temporal resolution is a key challenge in elucidating their chemistry in living systems. Recent progress in the development of fluorescent probes that respond selectively to NO and H(2)O(2) produced at cell signaling levels offers a promising approach to interrogating their physiological production, accumulation, trafficking, and function.

Source: PubMed

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Keywords

cell signaling levels
 
essential small molecules
 
hydrogen peroxide
 
interrogating
 
Inventing new ways
 
key challenge
 
Nitric oxide
 
oxidative posttranslational modifications
 
physiological production
 
promising approach
 
reactive species
 
small
 
systems