Article

Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats.

School of Psychology, University of Sydney, A19 NSW 2006, Australia.
European Journal of Pharmacology (impact factor: 2.52). 01/2004; 482(1-3):339-41. pp.339-41
Source: PubMed

ABSTRACT 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30 degrees C) relative to normal laboratory temperature (21 degrees C). In the intravenous drug self-administration paradigm, hot temperature (30 degrees C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.

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Keywords

21 degrees C
 
3,4-Methylenedioxymethamphetamine
 
30 degrees C
 
Ecstasy"
 
greater prosocial effects
 
hot conditions
 
intravenous drug self-administration paradigm
 
MDMA infusions
 
nightclubs
 
normal laboratory temperature
 
rats
 
social
 
social interaction paradigm