Retrospective motion gating in small animal CT of mice and rats.

Soenke H Bartling, Wolfram Stiller, Michael Grasruck, Bernhard Schmidt, Peter Peschke, Wolfhard Semmler, Fabian Kiessling

Junior Group Molecular Imaging, Department of Medical Physics in Radiology, German Research Center (DKFZ), Heidelberg, Germany.

Journal Article: Investigative Radiology (impact factor: 4.85). 11/2007; 42(10):704-14. DOI: 10.1097/RLI.0b013e318070dcad

Abstract

OBJECTIVES: Implementation and evaluation of retrospective respiratory and cardiac gating of mice and rats using a flat-panel volume-CT prototype (fpVCT). MATERIALS AND METHODS: Respiratory and cardiac gating was implemented by equipping a fpVCT with a small animal monitoring unit. ECG and breathing excursions were recorded and 2 binary gating signals derived. Mice and rats were scanned continuously over 80 seconds after administration of blood-pool contrast media. Projections were chosen to reconstruct volumes that fall within defined phases of the cardiac/respiratory cycle. RESULTS: Multireader analysis indicated that in gated still images motion artifacts were strongly reduced and diaphragm, tracheobronchial tract, heart, and vessels sharply delineated. From 4D series, functional data such as respiratory tidal volume and cardiac ejection fraction were calculated and matched well with values known from literature. DISCUSSION: Implementation of retrospective gating in fpVCT improves image quality and opens new perspectives for functional cardiac and lung imaging in small animals.

Source: PubMed

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  • Researcher
    Erratum:
    There is a radiation dose provided in the discussion part of the paper. This dose is not a good estimate of the actual mouse of rat dose, because a head phantom was used when the dose was measured. Most likely the dose is 2-3 fold higher.
    The actual dose measurement stems from:
    Ultra-high resolution flat-panel volume CT: fundamental principles, design architecture, and system characterization.
    Gupta R, Grasruck M, Suess C, Bartling SH, Schmidt B, Stierstorfer K, Popescu S, Brady T, Flohr T.
    Eur Radiol. 2006 Jun;16(6):1191-205. Epub 2006 Mar 10.

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Keywords

2 binary gating signals
 
4D series
 
80 seconds
 
blood-pool contrast media
 
breathing excursions
 
ECG
 
flat-panel volume-CT prototype
 
fpVCT
 
image quality
 
lung imaging
 
new perspectives
 
phases
 
rats
 
respiratory tidal volume
 
retrospective gating
 
retrospective respiratory
 
small animal monitoring unit
 
small animals
 
tracheobronchial tract
 
volumes