Papillary carcinoma, a rare malignant tumor of the breast, accounts for only 1-2% of breast tumors. It predominantly affects elderly women in the sixth decade to the eighth decade of life. The incidence of bilateral papillary carcinomas is very low, with only one case reported in the literature. However, there has been no report of a case of bilateral invasive papillary carcinoma. A case of bilateral invasive papillary carcinoma of the breasts, along with mammography and ultrasound findings, is reported here.
[Show abstract][Hide abstract] ABSTRACT: We present the case of a 55-year-old postmenopausal female who presented with complaints of a gradually increasing painless subareolar mass in the left breast of 4 months' duration. Left-sided modified radical mastectomy was performed and the specimen was histopathologically diagnosed as invasive papillary carcinoma. Immunohistochemistry confirmed this diagnosis. All 8 excised axillary lymph nodes were negative for malignant cells. Postoperative chemotherapy was given and for the past 6 months, the patient has maintained a regular follow-up on an outpatient basis. She does not have any evidence of either local or distant recurrence of tumour metastases.
Case Reports in Oncology 11/2010; 3(3):410-415. DOI:10.1159/000321270
[Show abstract][Hide abstract] ABSTRACT: Purpose:
Although patients with invasive papillary carcinoma (IPC) often have favorable prognoses, it remains unclear whether this special type of breast cancer represents a distinct morphological entity with its own biological features and clinical behavior distinct from those of invasive ductal carcinoma (IDC) and whether its four molecular subtypes are associated with different prognoses.
The study is a retrospective analysis of a large patient cohort from a single institution. 284 IPC samples were collected from January 2000 to May 2011. 300 IDC cases were selected randomly from 13,428 cases of IDC during the same periods. We assessed the clinicopathologic characteristics, molecular features, and prognostic value of IPC (n = 284) and compared them to those of IDC (n = 300). Clinicopathologic features and survival status of the four subtypes of IPC were also evaluated.
IPC differed from IDC with respect to age upon diagnosis, tumor grade, lymph node status, and menopausal status (P < 0.05). IPC was associated with a better 5-year overall survival rate (OS) (92.77 vs. 87.95 %) and disease-free survival rate (DFS) (87.95 vs. 80.72 %) than IDC. Tumors of the luminal A subtype had a better 5-year OS (97.78 %) and DFS (95.56 %) than other subtypes.
The biologic behavior of IPC is more favorable to patient outcome than that of IDC. The chance of pure IPC causing death without an intervening event of a different histologic type is exceptionally low. Luminal A subtypes have better outcomes when compared to the other subtypes.
Journal of Cancer Research and Clinical Oncology 08/2012; 139(1). DOI:10.1007/s00432-012-1302-3 · 3.08 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Papillary carcinoma is a rare malignant tumour of the breast with an incidence of 1-2% in the general population. The clinical behaviour of solid papillary carcinomas is generally indolent unless it is associated with invasion. Here, we are reporting two cases of solid invasive papillary carcinomas of the breast, who were 2 female patients aged 44 years and 55 years., with breast masses which were diagnosed by FNAC and confirmed by histopathology. The exact incidence and the clinical behaviours of such cases need to be ascertained by further research.
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