Adipokines, soluble mediators produced by adipocytes, may link adipose tissue to the inflammatory, metabolic, and immune dysregulation that characterize many obesity-related diseases. The stability of plasma adipokine levels within individuals, their seasonal variability, intercorrelations, and relationships to well-established measures of adiposity are incompletely defined. We measured levels of 12 adipokines [interleukin 1beta (IL-1beta), IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha), plasminogen activator inhibitor-1 (PAI-1), high-sensitivity C-reactive protein (hsCRP), monocyte chemoattractant protein-1 (MCP-1), nerve growth factor (NGF), leptin, adiponectin, hepatocyte growth factor (HGF), and resistin] in four seasonal random plasma samples of 48 male participants of a population-based cohort study. The representativeness of single measurements was assessed by correlating the adipokine levels of a single, random sample with the mean levels from the remaining three samples using a bootstrap approach and using intra-class correlation coefficients (ICC). Spearman correlations between adipokine levels, age, body mass index (BMI), and waist-to-hip ratio (WHR) were estimated. Correlations between plasma adipokine levels from one random sample and the mean of the remaining three seasonal samples ranged from 0.57 to 0.89. Over the 1-year study period, the ICCs for adipokine levels ranged from 0.44 (PAI-1) to 0.83 (HGF). IL-8, MCP-1, and resistin levels were positively associated with age; HGF and PAI-1 levels were correlated with BMI and WHR. This study suggests that adipokine levels in a single blood sample may be useful biomarkers of inflammation in population-based studies of obesity-related disease.
"Hazard ratios of CHD and 95% confidence intervals were estimated using Cox regression with age as the timescale. Measurements of plasma biomarkers have been described previously and shown reasonable intra-assay and intraperson coefficients of variation . Multivariable-adjusted geometric means of biomarkers by soy protein intake were calculated and compared using linear regression. "
[Show abstract][Hide abstract] ABSTRACT: Soy foods Coronary heart disease Men Prospective cohort study Interleukin-8 Plasminogen activator inhibitor-1 Soy food intake has been associated with a reduced risk of coronary heart disease (CHD) in women, but its association with CHD in men is unclear [1–3]. Several studies have found sex differences in the associa-tions of soy intake with metabolic syndrome, endothelial function, and other cardiovascular risk factors [4,5]. In the Shanghai Men's Health Study , we investigated the association between soy food intake and incident CHD among 55,474 Chinese men (40–74 years) who were free of CHD, stroke, and cancer at baseline (2002–2006). We also examined the associations of soy intake with multiple CHD biomarkers in a subsample of 3885 men who provided fasting blood samples and had no history of major chronic diseases at recruitment.
International Journal of Cardiology 03/2014; 172(2). DOI:10.1016/j.ijcard.2013.12.200 · 4.04 Impact Factor
"This limitation of relying on a single blood sample is common in most surveys , and there is some statistical compensation gained by the use of large subject numbers. In addition, some papers have reported that a single assessment can be representative of IL-6 levels over an extended period of time in both Americans and Chinese samples (Hofmann et al., 2011; Lee et al., 2007; Rao et al., 1994) as well as to predict myocardial infarction and diabetes even years later (Harris et al.,1999; Pradhan et al., 2001; Ridker et al., 2000). At the same time, some have found some variability in IL-6 levels over time (Navarro et al., 2012). "
[Show abstract][Hide abstract] ABSTRACT: Previous studies conducted in Western cultures have shown that negative emotions predict higher levels of pro-inflammatory biomarkers, specifically interleukin-6 (IL-6). This link between negative emotions and IL-6 may be specific to Western cultures where negative emotions are perceived to be problematic and thus may not extend to Eastern cultures where negative emotions are seen as acceptable and normal. Using samples of 1044 American and 382 Japanese middle-aged and older adults, we investigated whether the relationship between negative emotions and IL-6 varies by cultural context. Negative emotions predicted higher IL-6 among American adults, whereas no association was evident among Japanese adults. Furthermore, the interaction between culture and negative emotions remained even after controlling for demographic variables, psychological factors (positive emotions, neuroticism, extraversion), health behaviors (smoking status, alcohol consumption), and health status (chronic conditions, BMI). These findings highlight the role of cultural context in shaping how negative emotions affect inflammatory physiology and underscore the importance of cultural ideas and practices relevant to negative emotions for understanding of the interplay between psychology, physiology, and health. (172 words).
"TPA correlated with sTNFRI in the whole tendinosis group and in men with tendinosis but not in women with tendinosis, although the correlation coefficient was of similar magnitude (r 5 0.67, P 5 0.07). Therefore, on the whole, one can say that the more patients with Achilles tendinosis are physically active, the more is the TNF system activated, keeping in mind that sTNFRI is considered a stable marker of overall system activation (Lee et al., 2007). The underlying premise for this assertion is a normal feedback mechanism, whereby shedding of TNF receptors is increased after stimulation with TNF-a. "
[Show abstract][Hide abstract] ABSTRACT: Physical activity affects the pain symptoms for Achilles tendinosis patients. Brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNF-α) and their receptors have been detected in human Achilles tendon. This pilot study aimed to compare serum BDNF and soluble tumor necrosis factor receptor I (sTNFRI) levels in Achilles tendinosis patients and healthy controls and to examine the influence of physical activity, and BMI and gender, on these levels. Physical activity was measured with a validated questionnaire, total physical activity being the parameter analyzed. Physical activity was strongly correlated with BDNF among tendinosis women [Spearman's rho (ρ)=0.90, P<0.01] but not among control women (ρ=-0.08, P=0.83), or among tendinosis and control men. Physical activity was significantly correlated with sTNFRI in the entire tendinosis group and among tendinosis men (ρ=0.65, P=0.01), but not in the entire control group or among control men (ρ=0.04, P=0.91). Thus, the physical activity pattern is related to the TNF and BDNF systems for tendinosis patients but not controls, the relationship being gender dependent. This is new information concerning the relationship between physical activity and Achilles tendinosis, which may be related to pain for the patients. This aspect should be further evaluated using larger patient materials.
Scandinavian Journal of Medicine and Science in Sports 08/2011; 21(6):e430-8. DOI:10.1111/j.1600-0838.2011.01358.x · 2.90 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.