Article

Microalbuminuria, peripheral artery disease, and cognitive function.

University of North Carolina Kidney Center, CB no. 7156, 6005 Burnett Womack Building, Chapel Hill, North Carolina 27599-7156, USA.
Kidney International (impact factor: 6.61). 03/2008; 73(3):341-6. DOI:10.1038/sj.ki.5002672 pp.341-6
Source: PubMed

ABSTRACT Kidney disease may be linked to a decline in cognitive activity. We examined the association of microalbuminuria and cognitive function in a general population of older adults in the United States drawn from the National Health and Nutrition Examination Survey of 1999-2002. Cognitive function was measured by digit symbol substitution in 2,386 participants 60 years of age and older of whom 448 had microalbuminuria. Covariates included age, gender, race/ethnicity, education, smoking, diabetes, and hypertension. Among participants with peripheral artery disease, those with microalbuminuria had a significantly lower cognitive function score compared to those with a normal albumin-to-creatinine ratio. The association between microalbuminuria and cognitive function was weak in those without peripheral artery disease. But in those with peripheral artery disease, the odds of microalbuminuria associated with cognitive function in the lowest and middle tertiles was 6.5 and 3.5, respectively.

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Keywords

cognitive activity
 
Cognitive function
 
Covariates
 
digit symbol substitution
 
general population
 
hypertension
 
lower cognitive function score
 
microalbuminuria
 
middle tertiles
 
Nutrition Examination Survey
 
older
 
older adults
 
peripheral artery disease
 
race/ethnicity
 
United States