Hangai M, Kaneoka K, Kuno S, et al. Factors associated with lumbar intervertebral disc degeneration in the elderly

Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba, Ibaraki, 305-8575, Japan.
The Spine Journal (Impact Factor: 2.8). 12/2007; 8(5):732-40. DOI: 10.1016/j.spinee.2007.07.392
Source: PubMed

ABSTRACT Lumbar intervertebral disc degeneration (DD) precedes degenerative diseases of the lumbar spine. Various factors in addition to normal aging are reported to be associated with DD, and recently atherosclerosis and risk factors for cardiovascular diseases (cardiovascular risk factors) have received much attention; however, the links between these risk factors and DD are unclear.
By correlating magnetic resonance images (MRI) with suspected degenerative disc risk factors such as obesity, cardiovascular risk factors, and atherosclerosis, we hope to clarify the factors associated with DD.
An observational study.
Two hundred seventy adults (51-86 years old) who participated in a health promotion program.
DD evaluated based on the signal intensity of MR T2-weighted mid-sagittal images of the lumbar spine.
Age, gender, body mass index (BMI), low-density lipoprotein cholesterol (LDLc), triglyceride (TG), glycosylated hemoglobin (HbA(1c)), brachial-ankle pulse wave velocity (baPWV) as an index of atherosclerosis, osteo-sono-assessment index (OSI) calculated from quantitative ultrasound assessment of the calcaneus as an index of bone mineral density (BMD), history of low back pain (LBP), smoking and drinking habits, and physical loading related to occupations and sports were assessed. The univariate relationships between DD and the variables were evaluated, and finally, odds ratios (OR) and 95% confidence intervals (CI) for the associations of each factor with DD were calculated using logistic regression at each disc level.
Aging correlated significantly with DD of L1/2 (OR, 2.14), L2/3 (OR, 3.56), L3/4 (OR, 2.84), and L4/5 (OR, 3.05); high BMI, with L2/3 (OR, 2.98), L3/4 (OR, 3.58), L4/5 (OR, 2.32), and L5/S1 (OR, 3.34); high LDLc, with L4/5 (OR, 2.65); occupational lifting, with L1/2 (OR, 4.25); and sports activities, with L5/S1 (OR, 3.36).
Aging, high BMI, high LDLc, occupational lifting, and sports activities are associated with DD. The results of this study raise our index of suspicion that cardiovascular risk factors and particular physical loading may contribute to DD; however additional studies are required to further investigate associations between DD and these factors.

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Available from: Shinya Kuno, Aug 20, 2015
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    • "Biomechanical factors such as repetitive bending and twisting, routine tasks and vibrations increase the risk of LBDs in workplaces [3]. Excessive mechanical loads acting on the human spine as well as mechanical instability of the spine during daily/occupational/physical activities, amongst others, are known as important causes of LBDs [4] [5]. While there exists no direct method to measure spinal loads in vivo [3] some indirect approaches including intradiscal pressure measurement [6] to estimate disc compressive force and electromyography (EMG) [7] to predict muscle forces are proposed. "
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    ICBME; 12/2013
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    • "LBP has a multi-factorial etiology and risk factors are categorized as: job, individual, or psychosocial (Bernard, 1997). Among job physical demands, lifting and forceful movements were found to be strongly associated with LBP (Punnett et al., 1991; Bernard, 1997; Hangai et al., 2008). "
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    ABSTRACT: LBP is a major public health concern with enormous human and economic burden. The validity of the Revised NIOSH Lifting Equation (RNLE), a widely used job assessment tool, has not been studied previously in individuals with past LBP. The primary aim of this research was to study the relationship between RNLE measures and incident LBP episode risk after a 90-day pain free period using a prospective study design. One hundred and thirty industrial workers were identified as eligible to become an incident case for LBP. Univariate relationships between RNLE measures and incidence of LBP episode were studied using the Cox proportional hazards model. Significant associations between RNLE measures and incident LBP risk were found. It is concluded that the RNLE is predictive of incident LBP episode risk in individuals with past pain.
    Proceedings of the Human Factors and Ergonomics Society Annual Meeting; 09/2012
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    • "Although the relationship between vascular disease and LBP has the potential for major healthcare impact if it exists, the question of pain production involves a multitude of interrelated factors, including spinal degeneration, pain neurobiology, and psychosocial factors; vascular disease may or may not represent one component of many contributing to this complex interplay. The findings of the current study suggest that the potential link between vascular disease and LBP may be mediated by factors other than DHL; other possible intermediates include the pathoanatomical changes of disc desiccation[35], vertebral osteophytosis[32], endplate sclerosis, or facet joint osteoarthritis[36]. "
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    ABSTRACT: Vascular disease has been proposed as a risk factor for disc height loss (DHL). To examine the relationship between quantitative measures of abdominal aortic calcifications (AACs) as a marker of vascular disease, and DHL, on computed tomography (CT). Cross-sectional study in a community-based population. Four hundred thirty-five participants from the Framingham Heart Study. Quantitative AAC scores assessed by CT were grouped as tertiles of "no" (reference), "low," and "high" calcification. Disc height loss was evaluated on CT reformations using a four-grade scale. For analytic purposes, DHL was dichotomized as moderate DHL of at least one level at L2-S1 versus less than moderate or no DHL. We examined the association of AAC and DHL using logistic regression before and after adjusting for cardiovascular risk factors and before and after adjusting for age, sex, and body mass index (BMI). In crude analyses, low AAC (odds ratio [OR], 2.05 [1.27-3.30]; p=.003) and high AAC (OR, 2.24 [1.38-3.62]; p=.001) were strongly associated with DHL, when compared with the reference group of no AAC. Diabetes, hypercholesterolemia, hypertension, and smoking were not associated with DHL and did not attenuate the observed relationship between AAC and DHL. Adjustment for age, sex, and BMI markedly attenuated the associations between DHL and low AAC (OR, 1.20 [0.69-2.09]; p=.51) and high AAC (OR, 0.74 [0.36-1.53]; p=.42). Abdominal aortic calcification was associated with DHL in this community-based population. This relationship was independent of cardiovascular risk factors. However, the association of AAC with DHL was explained by the effects of age, sex, and BMI.
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