Article

Accuracy and precision in the detection of articular cartilage lesions using magnetic resonance imaging at 1.5 Tesla in an in vitro study with orthopedic and histopathologic correlation.

Department of Diagnostic Radiology, University Hospital Schleswig-Holstein Campus Kiel, Germany.
Acta Radiologica (impact factor: 1.37). 01/2008; 48(10):1131-7. DOI:10.1080/02841850701549583
Source: PubMed

ABSTRACT Magnetic resonance (MR) sequences for cartilage visualization have been the target of numerous studies, and the optimal sequence for cartilage imaging remains a matter of debate in the literature.
To compare MR findings with different MR sequences for the detection of cartilage lesions in fresh deep-frozen human cadaveric patellae in an in vitro setting.
Ten cadaveric patellae were imaged on a 1.5T MR scanner with a 2x2 channel carotid sandwich coil and a conventional knee coil, and compared with orthopedic findings and gold-standard histopathology. MR sequences were: a) fat-saturated (FS) proton density-weighted (PDw) turbo spin-echo (TSE) sequence (TR/TE 4000/39 ms); b) T2-weighted (T2w) double-echo steady-state (DESS) 3D water-excitation (we) sequence (TR/TE 17/4.7 ms); c) 3D-PDw-SPACE (sampling perfection with application-optimized contrasts using different flip-angle evolutions)-we sequence (TR/TE 1800/19 ms). Accuracy, Kendall's tau-b correlation, and weighted kappa coefficients were calculated.
Accuracy for cartilage lesion detection with the FS PDw-TSE sequence and the carotid coil was 78.3%, and with the knee coil 73.9%. For the T2wDESS-3D-we sequence, the corresponding values were 69.5% and 65.2%, and for the 3D-PDw-SPACE-we sequence 65.2% and 60.8%, respectively. Kendall's tau-b correlation ranged between 0.508 for the 3D-PDw-SPACE-we sequence (knee coil) and 0.720 for the FS PDw-TSE sequence (carotid and knee coil). Weighted kappa coefficient was lowest for the 3D-PDw-SPACE-we sequence (knee coil) at 0.607, and highest for the carotid coil and FS PDw-TSE sequence at 0.779.
The evaluated FS PDw-TSE sequences are superior in comparison to the T2wDESS-3D-we and 3D-PDw-SPACE-we sequences in the in vitro setting for the detection of cartilage lesions, and are comparable to results reported in the literature.

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Keywords

1.5T MR scanner
 
2x2 channel carotid sandwich coil
 
3D-PDw-SPACE-we sequence
 
3D-PDw-SPACE-we sequence 65.2%
 
3D-PDw-SPACE-we sequences
 
carotid coil
 
cartilage imaging
 
cartilage lesion detection
 
cartilage visualization
 
conventional knee coil
 
different flip-angle evolutions)-we sequence
 
different MR sequences
 
evaluated FS PDw-TSE sequences
 
FS PDw-TSE sequence
 
kappa coefficient
 
knee coil
 
MR sequences
 
optimal sequence
 
T2wDESS-3D-we sequence
 
weighted kappa coefficients