Characteristics of clock drawing test (CDT) errors by the dementia type: Quantitative and qualitative analyses
ABSTRACT We wanted to define the characteristics of errors on the clock drawing test (CDT) and we also wanted to determine their value for making the early diagnosis of dementia, so the performance of patients with three types of dementia on the four CDT was evaluated. The patients with subcortical vascular dementia (VaD) and patients with Parkinson's disease with dementia (PDD) had more stimulus bound responses. Patients with Alzheimer disease (AD) made significantly more conceptual deficit (CD) errors. The CD correlated with the severity of dementia and it could be detected in the early and mild stage of dementia. Qualitative and quantitative analyses of the errors on the CDT might be useful for making the early differential diagnosis of dementia types.
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- "Ng (2009) reported mean MMSE scores amongst different clinical conditions including hypertension and diabetes but found no significant associations with decline. In South Korea, Lee et al. (2009) found no significant relationship between MetS and overall cognitive abilities using the Korean version of MMSE (K- MMSE). However, it is important to note that the MMSE is a limited tool for the assessment of neuropsychological status and is unlikely to tap the subtle aspects of cognitive change in the MetS population. "
ABSTRACT: ABSTRACT Background: An association between metabolic syndrome (MetS) and disturbances in neurocognitive function has been identified in Caucasians but the nature and extent of impaired cognition in Asian MetS patients, who may be at greater risk of degenerative cognitive decline, remains unspecified. Methods: A cross-sectional study was conducted at the National University Hospital of Singapore. Participants were recruited from a diabetes clinic at the National University Hospital. Fifty-three patients who met MetS criteria and 44 clinical controls were recruited. All participants were 55 years and above and community ambulant. Neurocognitive function was assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB). CANTAB performances between MetS and control groups were examined with analysis of variance (ANOVA) and the relative contributions of vascular risk, and intrademographic factors on CANTAB scores were dilineated with stepwise regression analyses. Results: Participants with MetS consistently performed significantly worse than controls across all CANTAB subtests. Education and Chinese race were found to be potential protective factors. Conclusions: Executive and memory impairment is present in Asian patients with midlife MetS who may be particularly vulnerable to the detrimental impact of MetS in midlife.International Psychogeriatrics 05/2014; 26(8):1-12. DOI:10.1017/S104161021400057X · 1.89 Impact Factor
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- "On the basis of this result and to improve our knowledge about ADAM10 as a potential peripheral biomarker for AD, in this study, we correlated data on platelet ADAM10 expression and CDT, an extensively used test for the screening of cognitive impairments in the elderly patients. Additionally, CDT is an easy test to administrate and interpret, presenting high sensitivity and specificity (85%), and together with Verbal Fluency Test and Trail Making Test-B, is the main recommended to measure executive functioning (Lee et al., 2009; Bossers et al., 2012). Few studies have correlated CDT with AD biomarkers (Palmqvist et al., 2012), but several have used other cognitive tests to correlate with CSF biomarkers for AD (Buchhave et al., 2009; Llano et al., 2011; Ewers et al., 2012; Palmqvist et al., 2012) or blood biomarkers, such as amyloid precursor protein (APP) isoforms (Baskin et al., 2000; Borroni et al., 2003; Zainaghi et al., 2007). "
ABSTRACT: Earlier studies have demonstrated that a disintegrin and metallopeptidase 10 (ADAM10) levels are reduced in Alzheimer's disease (AD) patients compared with healthy subjects. The objective of this study was to evaluate whether platelet ADAM10 levels correlates with the clock drawing test (CDT) scores, which is a simple and a reliable measure of visuospatial ability and executive function in AD patients. Thirty elderly patients with probable AD and 25 healthy patients forming the control group, matched by age, gender, and educational level, were evaluated. Platelet proteins were analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis, and ADAM10 was identified by western blotting. The Spearman's correlation coefficient between ADAM10 and CDT was obtained for each group. The areas under the curves were used to compare the receiver operating characteristic curves. The CDT scores and platelet ADAM10 expression were significantly different between patients with AD and controls and also along the disease's progression. In AD patients, there was a positive correlation between ADAM10 expression and CDT scores. Among non-AD subjects, no correlation was found. The combination of ADAM10 and CDT was significantly better to confirm the AD diagnosis than the AUCs of ADAM10 and CDT separately. The association of blood-based biomarkers, such as ADAM10, and cognitive tests may be helpful for a more reliable AD diagnosis. Copyright © 2013 John Wiley & Sons, Ltd.International Journal of Geriatric Psychiatry 04/2014; 29(4). DOI:10.1002/gps.4020 · 3.09 Impact Factor
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ABSTRACT: O presente artigo tem como principal objectivo contribuir para o processo de valida- ção de uma adaptação para a língua portuguesa do “Questionário de Competência Interpessoal” (QCI; Buhrmester, Furman, Wittenberg e Reis, 1988). A amostra consistiu em 322 adolescentes e jovens adultos, com idades entre os 16 e os 25 anos de idade (M = 18.0, DP = .48). Foram levadas a cabo análises factoriais exploratórias e confirmatórias, bem como análises diferenciais em função do sexo e da idade. As análises exploratórias e confirmató- rias evidenciaram uma estrutura limpa, com as cinco dimensões originais do instrumento e índices adequados de ajustamento. A consistência interna das dimensões revelou valores satisfatórios e as correlações entre factores mostraram-se em conformidade com o enquadramento teórico. O instrumento mostrou-se igualmente sensível na identificação de diferenças em função do sexo e da idade. São discutidas as implicações e limitações deste estudo para futuras investigações.