Genetic regulation of cardiogenesis and congenital heart disease.

Gladstone Institute of Cardiovascular Disease, Department of Pediatrics, University of California, San Francisco, California 94158, USA.
Annual Review of Pathology Mechanisms of Disease (Impact Factor: 25.79). 02/2006; 1:199-213. DOI: 10.1146/annurev.pathol.1.110304.100039
Source: PubMed

ABSTRACT Developmental heart disorders are the most common of all human birth defects and occur in nearly one percent of the population. Survivors of congenital heart malformations are an increasing population, and it is becoming clear that genetic mutations that cause developmental anomalies may result in cardiac dysfunction later in life. This review highlights the progress in understanding the underlying molecular basis for cardiac formation and how disruption of the intricate steps of cardiogenesis can lead to congenital heart defects. The lessons learned from examining the early steps of heart formation are essential for informing the prevention of malformations and their long-term consequences, as well as for approaches to guide stem cells into cardiac lineages.

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