Bone marrow metastasis of desmoplastic small round cell tumor.

Department of Medical Oncology, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China.
Tumori (Impact Factor: 1.27). 01/2007; 93(5):511-3.
Source: PubMed

ABSTRACT Desmoplastic small round cell tumor is an extremely rare and highly aggressive neoplasm. It usually arises as a single mass or multiple masses in the abdominal cavity, characterized by diffuse peritoneal implants, involvement of regional lymph nodes, and liver and lung metastases. However, bone marrow metastasis has rarely been reported in the literature. We present a case of clinically symptomatic bone marrow metastasis in a 25-year-old woman with a diagnosis of desmoplastic small round cell tumor originating from the pelvic cavity.

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    ABSTRACT: Intraabdominal desmoplastic small round cell tumor (IDSRCT) is a rare tumor with poor prognosis that usually develops in the peritoneal cavity, often in childhood and adolescence. This tumor typically arises as single or multiple masses, and is characterized by diffuse peritoneal implants and the involvement of regional lymph nodes. Because most patients are unable to achieve a complete response with chemotherapy alone, extensive efforts have been made to develop more effective chemotherapy regimens. Here, we report on a case of IDSRCT in a 33-year-old man treated with ifosfamide (IFM)-based chemotherapy. Before treatment initiation, the patient had extensive ascites in the peritoneal cavity and was experiencing abdominal fullness and anorexia. Currently, 8months after his initial presentation, he is still undergoing chemotherapy and is in good general condition.
    Clinical Journal of Gastroenterology 02/2010; 3(1):25-29. DOI:10.1007/s12328-009-0131-7


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