Stress-induced immune dysregulation: Implications for wound healing, infectious disease and cancer

Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA.
Journal of Neuroimmune Pharmacology (Impact Factor: 3.17). 01/2007; 1(4):421-7. DOI: 10.1007/s11481-006-9036-0
Source: PubMed

ABSTRACT The communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine and immune systems. The field of psychoneuroimmunology (PNI) has provided new insights to help understand the pathophysiological processes that are linked to the immune system. Work in this field has established that psychological stress disrupts the functional interaction between the nervous and immune systems. Stress-induced immune dysregulation has been shown to be significant enough to result in health consequences, including reducing the immune response to vaccines, slowing wound healing, reactivating latent herpesviruses, such as Epstein-Barr virus (EBV), and enhancing the risk for more severe infectious disease. Chronic stress/depression can increase the peripheral production of proinflammatory cytokines, such as interleukin (IL)-6. High serum levels of IL-6 have been linked to risks for several conditions, such as cardiovascular disease, type 2 diabetes, mental health complications, and some cancers. This overview will discuss the evidence that psychological stress promotes immune dysfunction that negatively impacts human health.

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Available from: Jonathan Godbout, Apr 21, 2015
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    Journal of Advanced Research 04/2015; 103. DOI:10.1016/j.jare.2015.04.001
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    • "Gene set enrichment analysis of these 123 genes revealed that, compared to controls, anxious men had altered gene expression in biological pathways involving immune responses to acute viral or bacterial infection, as well as to influenza vaccination in a variety of immune cells, including monocytes, macrophages, myeloid dendritic cells, B cells, neutrophils, and mast cells. As mentioned earlier, clinical and epidemiological studies found that anxiety has a negative impact on immune functions (Godbout and Glaser, 2006; Arranz et al., 2007) as reflected by reduced immune response to vaccinations (Miller et al., 2004; Vedhara et al., 1999; Glaser et al., 1992; Morag et al., 1999; Burns et al., 2002), reactivation of latent herpes virus (Cohen et al., 1999), and increasing risk of infectious diseases (Sareen et al., 2005; Cohen et al., 1991). Our results are consistent with these epidemiological findings and shed some light on the molecular pathways in various immune cells by which anxiety can affect immune functioning. "
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