The management of cancer-related fatigue after chemotherapy with acupuncture and acupressure: A randomised controlled trial. Complementary Therapies in Medicine, 15, 228-237

University of Manchester, School of Nursing, Midwifery & Social Work, Coupland III, Coupland Street, Manchester M13 9PL, UK.
Complementary Therapies in Medicine (Impact Factor: 1.55). 12/2007; 15(4):228-37. DOI: 10.1016/j.ctim.2006.09.009
Source: PubMed


Cancer-related fatigue after chemotherapy is a difficult symptom to manage in practice and the most disruptive symptom in patients' lives. Acupuncture is a popular complementary therapy among cancer patients and some evidence exists that it could potentially alleviate fatigue by stimulating 'energy' points in the body. Hence, this study was carried out to assess the effects of acupuncture and acupressure in managing cancer-related fatigue and the feasibility of running a randomised trial with these two complementary therapies in preparation for a large trial.
This study was a randomised controlled trial. Forty-seven patients with cancer who experienced moderate to severe fatigue were randomised either to an acupuncture group (n=15), an acupressure group (n=16) or a sham acupressure group (n=16). The acupuncture group received six 20-min sessions over 2 weeks, while the patients in the two acupressure groups were taught to massage/press the points and did so daily thereafter for 2 weeks on their own. Patients completed the Multidimensional Fatigue Inventory before randomisation, at the end of the 2-week intervention and again about 2 weeks after the end of the intervention.
Significant improvements were found with regards to General fatigue (P<0.001), Physical fatigue (P=0.016), Activity (p=0.004) and Motivation (P=0.024). At the end of the intervention, there was a 36% improvement in fatigue levels in the acupuncture group, while the acupressure group improved by 19% and the sham acupressure by 0.6%. Improvements were observed even 2 weeks after treatments, although they were lower (22%, 15%, 7%, respectively). Acupuncture was a more effective method than acupressure or sham acupressure. Subjects needed a longer treatment period to have more sustained results. The trial was methodologically feasible.
Acupuncture shows great potential in the management of cancer-related fatigue. As a randomised trial with acupuncture is feasible and preliminary data shows significant improvements, it should be tested further using a large sample and a multicentre design.

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Available from: Alex Molassiotis, Oct 13, 2015
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    • "In a prospective phase II study on patients with persistent fatigue who had previously completed chemotherapy, acupuncture resulted in a significant reduction in baseline fatigue scores [212]. Further four RCTs showed that acupuncture was associated with a significant improvement in general fatigue scores [213–216]. "
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    • "(1) The total numbers of RCTs and participants involved were too small to draw concrete conclusions on the therapeutic effect of acupuncture and moxibustion. (2) Four trials (Molassiotis et al., 2007; Balk et al., 2009; Molassiotis et al., 2012; Smith et al., 2012) concentrated on acupuncture possessed relatively high quality, yet three studies (Chen et al., 2011; Qin et al., 2012; Yang et al., 2012) concerning moxibustion were noted not a few drawbacks, namely, the missing information of adverse effects and low methodological quality described above. Nevertheless, it cannot be avoided owning to the restriction of inherent literatures resource. "
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