Article

Gender differences in presentation and course of disease in pediatric patients with Crohn disease

Department of Pediatrics, The Children's Hospital of Philadelphia, Filadelfia, Pennsylvania, United States
PEDIATRICS (Impact Factor: 5.3). 01/2008; 120(6):e1418-25. DOI: 10.1542/peds.2007-0905
Source: PubMed

ABSTRACT The objective of this study was to determine gender differences in pediatric patients with Crohn disease.
We conducted a retrospective cohort study of 989 consecutive pediatric patients (566 boys, 423 girls) who had Crohn disease (aged 0 to 17 years at diagnosis) by using the Pediatric IBD Consortium Registry. Uniform data were analyzed to compare the presentation and course of disease according to gender.
Median follow-up time was 2.8 years. Mean +/- SD age at diagnosis of inflammatory bowel disease (11.5 +/- 3.8 years) did not differ by gender. Compared with boys, girls had a higher prevalence of mouth sores at symptom onset and a higher prevalence of hypoalbuminemia at the time of diagnosis. Location of disease did not differ by gender. A higher proportion of girls had abnormal anti-outer membrane porin of Escherichia coli levels compared with boys. Girls were at increased risk for erythema nodosum/pyoderma gangrenosum and decreased risk for growth failure compared with boys.
Girls appear to have an overall more severe course of disease; however, boys are at increased risk for developing growth failure. Disease course and the impact of disease severity on growth according to gender in pediatric Crohn disease require prospective study.

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    • "Men develop autoimmune hepatitis at a younger age and have high relapse rates, but also have better prognosis than women (Al-Chalabi et al., 2008). By contrast, the clinical course in CD is more severe in girls (Gupta et al., 2007), whereas in diseases like RA, gender does not necessarily predict outcome (Courvoisier et al., 2008). In MS, disease severity, measured as disability progression , appears to be greater in males (Runmarker and Andersen, 1993; Weinshenker et al., 1991). "
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    Frontiers in Neuroendocrinology 04/2014; 35(3). DOI:10.1016/j.yfrne.2014.04.004 · 7.58 Impact Factor
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    • "Men develop autoimmune hepatitis at a younger age and have high relapse rates, but also have better prognosis than women (Al-Chalabi et al., 2008). By contrast, the clinical course in CD is more severe in girls (Gupta et al., 2007), whereas in diseases like RA, gender does not necessarily predict outcome (Courvoisier et al., 2008). In MS, disease severity, measured as disability progression , appears to be greater in males (Runmarker and Andersen, 1993; Weinshenker et al., 1991). "
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    ABSTRACT: Autoimmune diseases are a range of diseases in which the immune response to self-antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic or can affect specific organs or body systems. For most autoimmune diseases there is a clear sex difference in prevalence, whereby females are generally more frequently affected than males. In this review, we consider gender differences in systemic and organ-specific autoimmune diseases, and we summarize human data that outlines the prevalence of common autoimmune diseases specific to adult males and females in countries commonly surveyed. We discuss possible mechanisms for sex specific differences including gender differences in immune response and organ vulnerability, reproductive capacity including pregnancy, sex hormones, genetic predisposition, parental inheritance, and epigenetics. Evidence demonstrates that gender has a significant influence on the development of autoimmune disease. Thus, considerations of gender should be at the forefront of all studies that attempt to define mechanisms that underpin autoimmune disease.
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