Article

The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer

Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor 48109, USA.
Journal of Biological Chemistry (Impact Factor: 4.6). 03/2008; 283(7):4283-94. DOI: 10.1074/jbc.M707465200
Source: PubMed

ABSTRACT Several reports have recently documented that CXCR7/RDC1 functions as a chemokine receptor for SDF-1/CXCL12, which regulates
a spectrum of normal and pathological processes. In this study, the role of CXCR7/RDC1 in prostate cancer (PCa) was explored.
Staining of high density tissue microarrays demonstrates that the levels of CXCR7/RDC1 expression increase as the tumors become
more aggressive. In vitro and in vivo studies with PCa cell lines suggest that alterations in CXCR7/RDC1 expression are associated with enhanced adhesive and invasive
activities in addition to a survival advantage. In addition, it was observed that CXCR7/RDC1 levels are regulated by CXCR4.
Among the potential downstream targets of CXCR7/RDC1 are CD44 and cadherin-11, which are likely to contribute to the invasiveness
of PCa cells. CXCR7/RDC1 also regulates the expression of the proangiogenic factors interleukin-8 or vascular endothelial
growth factor, which are likely to participate in the regulation of tumor angiogenesis. Finally, we found that signaling by
CXCR7/RDC1 activates AKT pathways. Together, these data demonstrate a role for CXCR7/RDC1 in PCa metastasis and progression
and suggest potential targets for therapeutic intervention.

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Available from: Yusuke Shiozawa, Jul 01, 2015
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