Article

The ascent of cat breeds: Genetic evaluations of breeds and worldwide random-bred populations

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616, USA.
Genomics (Impact Factor: 2.79). 02/2008; 91(1):12-21. DOI: 10.1016/j.ygeno.2007.10.009
Source: PubMed

ABSTRACT The diaspora of the modern cat was traced with microsatellite markers from the presumed site of domestication to distant regions of the world. Genetic data were derived from over 1100 individuals, representing 17 random-bred populations from five continents and 22 breeds. The Mediterranean was reconfirmed to be the probable site of domestication. Genetic diversity has remained broad throughout the world, with distinct genetic clustering in the Mediterranean basin, Europe/America, Asia and Africa. However, Asian cats appeared to have separated early and expanded in relative isolation. Most breeds were derived from indigenous cats of their purported regions of origin. However, the Persian and Japanese bobtail were more aligned with European/American than with Mediterranean basin or Asian clusters. Three recently derived breeds were not distinct from their parental breeds of origin. Pure breeding was associated with a loss of genetic diversity; however, this loss did not correlate with breed popularity or age.

Download full-text

Full-text

Available from: Maria Longeri, Jan 06, 2014
0 Followers
 · 
175 Views
  • Source
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Domestic cats are not only a popular and beloved household pet, but also increasingly attracting attention within the scientific community as potential model organism for human hereditary and infectious diseases. Understanding genetic diseases in cats is central to the maintenance of healthy pets and has the potential to be used as a medical model for humans. In this era of genome-wide studies, insights about linkage disequilibrium (LD) are essential for successful association mapping. The objective of this study is to investigate the extent of LD in the domestic cat Felis catus, particularly within its breeds. To finely estimate LD in different populations, a custom Illumina GoldenGate Assay was developed for the domestic cat. The assay consisted of 1536 SNPs equally divided over 10 chromosomal regions. Approximately, 150 SNPs were distributed over a contiguous 1Mb region of each chromosome to allow detection of LD variation. Eighteen globally recognized cat breeds and two distinct random bred populations were selected for the analysis. Two LD descriptive measures (r2 and D`) were calculated pair-wise between the SNPs in each region and each population independently. LD decay was estimated by finding the non-linear least-squares of the pair-wise estimates as a function of distance. LD decay is fastest in random bred populations and varied across breeds. Significant LD in breeds ranged between several hundred kilobases to beyond 1Mb. Measures of LD in breeds reflect the recent breeding history, the small population size, and the levels of inbreeding.
    International Plant and Animal Genome Conference XX 2012;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Our knowledge of cat family biology was recently expanded to include a genomics perspective with the completion of a draft whole genome sequence of an Abyssinian cat. The utility of the new genome information has been demonstrated by applications ranging from disease gene discovery and comparative genomics to species conservation. Patterns of genomic organization among cats and inbred domestic cat breeds have illuminated our view of domestication, revealing linkage disequilibrium tracks consequent of breed formation, defining chromosome exchanges that punctuated major lineages of mammals and suggesting ancestral continental migration events that led to 37 modern species of Felidae. We review these recent advances here. As the genome resources develop, the cat is poised to make a major contribution to many areas in genetics and biology.
    Trends in Genetics 07/2008; 24(6):268-79. DOI:10.1016/j.tig.2008.03.004 · 11.60 Impact Factor
Show more