The Neuroendocrine Effects of Traumatic Brain Injury
ABSTRACT Neuroendocrine dysfunction after traumatic brain injury (TBI) is under-diagnosed, under-treated, and may adversely affect the rate of recovery. Single or multiple pituitary-target hormone disruption occurs in up to two-thirds of persons with TBI, most commonly affecting the gonadal and growth hormone axes. The time course of decline in and recovery of pituitary function in relation to cognitive dysfunction and rehabilitation progress are not well described. This article reviews the clinical spectrum of neuroendocrine deficits after TBI and their underlying mechanisms. Future studies of the effects of hormonal replacement on recovery are recommended.
- SourceAvailable from: Nadia Elizabeth Webb
03/2015; 11(1). DOI:10.14713/pcsp.v11i1.1886
- "Distress can interfere with neuronal health directly through alterations in the neuroendocrine system (Masel et al., 2010; Rothman et al., 2007), but distress can also interfere with physical health and sleep. The increased stress burden can diminish the resources a person can bring to problem solving. "
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ABSTRACT: Tesis Univ. Granada. Departamento de Radiología y Medicina Física. Leída el 12 de julio de 2010