Expression of Co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis.

The Bogomolets National Medical University, The Immunological Laboratory of the Institute of Urology, AMS of Ukraine.
Immunopharmacology and Immunotoxicology (Impact Factor: 1.36). 02/2007; 29(3-4):487-98. DOI: 10.1080/08923970701675101
Source: PubMed

ABSTRACT Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and the co-stimulatory molecules CD80 and CD86, expressed on functionally mature dendritic cells, were counted in lesional biopsies and normal epidermis by an immunohistochemical method. CD1a specific staining was observed in both normal and AD lesion specimens. CD80 and CD86 positive cells with morphological characteristics of the LC were found in lesional AD epidermis, suggesting a high level of functional maturity of these cells and their involvement in chronic inflammatory disease.

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