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Synapse remodeling, compliments of the complement system.

Division of Biological Sciences, Section of Neurobiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Cell (Impact Factor: 33.12). 01/2008; 131(6):1034-6. DOI: 10.1016/j.cell.2007.11.031
Source: PubMed

ABSTRACT A growing body of evidence indicates that some proteins known for their immune functions also have distinct nonimmune functions in the normal uninjured central nervous system. In this issue, Stevens et al. (2007) demonstrate an unexpected requirement for molecules of the complement cascade in the remodeling of synaptic connections in the developing visual system.

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