Gill, S.E. & Parks, W.C. Metalloproteinases and their inhibitors: regulators of wound healing. Int. J. Biochem. Cell Biol. 40, 1334-1347

Center for Lung Biology, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA.
The International Journal of Biochemistry & Cell Biology (Impact Factor: 4.24). 02/2008; 40(6-7):1334-47. DOI: 10.1016/j.biocel.2007.10.024
Source: PubMed

ABSTRACT Wound healing is a dynamic process that involves a coordinated response of many cell types representing distinct tissue compartments and is fundamentally similar among tissue types. Among the many gene products that are essential for restoration of normal tissue architecture, several members of the matrix metalloproteinase (MMP) family function as positive and, at times, negative regulators of repair processes. MMPs were initially thought to only function in the resolution phase of wound healing, particularly during scar resorption; however, recent evidence suggests that they also influence other wound-healing responses, such as inflammation and re-epithelialization. In this review, we discuss what is currently known about the function of MMPs in wound healing and will provide suggestions for future research directions.

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    • "MMPs degrade the extracellular matrix which is general remodeling process that enables several pathologic conditions including inflammatory, vascular, and autoimmune disorders, and carcinogenesis as well as physiological processes like wound healing, bone resorption, uterine involution , and organogenesis (Egeblad and Werb, 2002; Lee and Murphy, 2004). These endopeptidases are made up of enzymes namely serralysins, astacins, adamalysins (a disintegrin and metalloproteinase domain or ADAMs), and matrixins (MMPs) which are from metzincin family (Gill and Parks, 2008). There are more than 20 enzymes that are broadly classified into 6 groups as shown in Table 1 (Velinov et al., 2010). "
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    ABSTRACT: Matrix metalloproteinases are endopeptidases which belong to the group of metalloproteinases that contribute for the extra-cellular matrix degradation, and several tissue remodeling processes. An imbalance in the regulation of these endopeptidases eventually leads to several severe pathological complications like cancers, cardiac, cartilage, and neurological related diseases. Hence inhibitory substances of metalloproteinases (MMPIs) could prove beneficial in the management of above specified pathological conditions. The available synthetic MMPIs that have been reported until now have few shortcomings and thus many of them could not make to the final clinical trials. Hence a growing interest among researchers on screening of MMPIs from different natural resources is evident and especially natural products from marine origin. As there has been an unparalleled contribution of several biologically active compounds from marine resources that have shown profound applications in nutraceuticals, cosmeceuticals, and pharmaceuticals, we have attempted to discuss the various MMPIs from edible sea-weeds.
    Environmental Toxicology and Pharmacology 04/2014; 37(3):1090-1100. DOI:10.1016/j.etap.2014.04.011 · 2.08 Impact Factor
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    • "A mildly acute inflammatory reaction attracted a large number of polymorphonuclear leukocytes and some macrophages to clean away debris and blood clots [2]. Also the secretion of cell cytokines and growth factors by these cells provided an excellent environment for wound healing [3] [4]. The migration of fibroblast cells, which was promoted by SACCHACHITIN, also plays another important role in accelerating wound healing [1]. "
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    ABSTRACT: LUFFACHITIN obtained from the residue of the sponge-like dried fruit of Luffa aegyptiaca was developed as a weavable skin substitute in this study. A chemical analysis revealed that LUFFACHITIN was composed of a copolymer containing N-acetyl-glucosamine (~40%) as a major monomer with a filamentary structure as demonstrated by both optical and scanning electron microscopy. The pulp-like white residue of the sponge-like dried fruit of Luffa aegyptiaca after treatment was then woven into a thin, porous membrane by filtration and lyophilization as a skin substitute for conducting wound-healing study on rats. The results indicated that the LUFFACHITIN membrane showed significant wound-healing enhancement (25 days to complete healing) compared to cotton gauze (>30 days), but not inferior to that of SACCHACHITIN. Furthermore, the LUFFACHITIN membrane had advantages of having a high yield, better physical properties for fabrication, and a more attractive appearance.
    04/2014; 2014:458287. DOI:10.1155/2014/458287
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    • "More recent studies of larval ASE help us see just how these proteolytic enzymes fit into the context of debridement and wound healing, for we now know that they include a wide array of matrix metalloproteinases (MMPs), including at least the trypsin-like and chymotrypsin-like serine proteases, an aspartyl proteinase, and an exopeptidaselike MMP, active across a wide pH range [12] [13] [14]. It is important to recognize that humans produce at least 23 different MMPs which not only degrade extracellular protein but also regulate a wide variety of cellular processes through activation (or deactivation) of signaling molecules and/or their receptors [15]. MMPs play critical roles in all phases of tissue repair and wound healing, including hemostasis, thrombosis, inflammatory cell activation, collagen degradation, fibroblast and keratinocyte migration, and tissue remodeling. "
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    ABSTRACT: MEDICINAL MAGGOTS ARE BELIEVED TO HAVE THREE MAJOR MECHANISMS OF ACTION ON WOUNDS, BROUGHT ABOUT CHEMICALLY AND THROUGH PHYSICAL CONTACT: debridement (cleaning of debris), disinfection, and hastened wound healing. Until recently, most of the evidence for these claims was anecdotal; but the past 25 years have seen an increase in the use and study of maggot therapy. Controlled clinical studies are now available, along with laboratory investigations that examine the interaction of maggot and host on a cellular and molecular level. This review was undertaken to extract the salient data, make sense, where possible, of seemingly conflicting evidence, and reexamine our paradigm for maggot-induced wound healing. Clinical and laboratory data strongly support claims of effective and efficient debridement. Clinical evidence for hastened wound healing is meager, but laboratory studies and some small, replicated clinical studies strongly suggest that maggots do promote tissue growth and wound healing, though it is likely only during and shortly after the period when they are present on the wound. The best way to evaluate-and indeed realize-maggot-induced wound healing may be to use medicinal maggots as a "maintenance debridement" modality, applying them beyond the point of gross debridement.
    Evidence-based Complementary and Alternative Medicine 03/2014; 2014:592419. DOI:10.1155/2014/592419 · 1.88 Impact Factor
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