Molecular analysis of rat mammary carcinogenesis: An approach from carcinogenesis research to cancer prevention

Second Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, Japan.
Medical Molecular Morphology (Impact Factor: 1.46). 01/2008; 40(4):185-90. DOI: 10.1007/s00795-007-0369-4
Source: PubMed


A rat strain carrying the human c-Ha-ras proto-oncogene is highly susceptible to chemically induced mammary carcinogenesis. All the transgenic rats develop preneoplastic mammary lesions within 20 days of an injection of N-methyl-N-nitrosourea, and mammary carcinomas appear within 8 weeks of treatment with a variety of chemical carcinogens. In this review, we summarize molecular aspects of mammary carcinogenesis in transgenic rats and the potential application of this model for studies of breast cancer prevention.

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