Quantitative EEG in early Alzheimer's disease patients - Power spectrum and complexity features

Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary.
International Journal of Psychophysiology (Impact Factor: 2.65). 05/2008; 68(1):75-80. DOI: 10.1016/j.ijpsycho.2007.11.002
Source: PubMed

ABSTRACT The goal of this study was to investigate the EEG signs of early stage Alzheimer's disease (AD) by conventional analyses and by methods quantifying linear and nonlinear EEG-complexity. The EEG was recorded in 12 mild AD patients and in an age-matched healthy control group (24 subjects) in both eyes open and eyes closed conditions. Frequency spectra, Omega-complexity and Synchronization likelihood were calculated on the data. In the patients a significant decrease of the relative alpha and increase of the theta power were found. Remarkably increased Omega-complexity and lower Synchronization likelihood were observed in AD in the 0.5-25 Hz frequency ranges. It is concluded that both spectral- and EEG-complexity changes can be found already in the early stage of AD in a wide frequency range. Application of conventional EEG analysis methods in combination with quantification of EEG-complexity may improve the chances of early diagnosis of AD.

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Jun 3, 2014