Pyogenic liver abscess complicating colonoscopic polypectomy.

Division of Gastroenterology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Gastrointestinal Endoscopy (Impact Factor: 4.9). 05/2008; 67(4):767-8. DOI: 10.1016/j.gie.2007.08.028
Source: PubMed
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    ABSTRACT: Colonic mucosal defects might be a route for bacterial invasion into the portal system, with subsequent hematogenous spread to the liver. We retrospectively investigated the results of colonoscopy and the clinical characteristics of patients with pyogenic liver abscess of colonic origin. A total of 230 consecutive patients with pyogenic liver abscess were reviewed between 2003 and 2010. The 230 patients were categorized into three groups (pancreatobiliary [n = 135], cryptogenic [n = 81], and others [n = 14]). Of the 81 cryptogenic patients, 37 (45.7%) underwent colonoscopy. Colonic lesions with mucosal defects were considered colonic causes of abscess. In the 37 colonoscopic investigations, colon cancer was found in six patients (16.2%), laterally-spreading tumor (LST) in two patients (5.4%), multiple colon ulcers in one patient (2.7%), colon polyps in 17 patients (45.9%), and diverticula in four patients (10.8%). Nine (11%) of 81 cryptogenic abscesses were therefore reclassified as being of colonic origin (colon cancer = 6, LST = 2, ulcer = 1). Three cases were stage III colon cancer, and the others were stage I. Two LST were high-grade dysplasia. The percentage of patients with Klebsiella pneumoniae (K. pneumoniae) and diabetes mellitus (DM) of colonic origin was 66.7%, which was significantly higher than the 8.6% for other causes (P < 0.001). Of the 37 patients with cryptogenic pyogenic liver abscess who underwent colonoscopy, nine (24.3%) were diagnosed with a colonic cause. Colonoscopy should be considered for the detection of hidden colonic malignant lesions in patients with cryptogenic pyogenic liver abscess, especially for patients with K. pneumoniae and DM.
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  • Gastrointestinal endoscopy 02/2009; 69(1):191. · 4.90 Impact Factor
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    ABSTRACT: Pyogenic liver abscess (PLA) is commonly seen in patients in the Far East. Similarly, hepatobiliary neoplasms are also common. PLA as the initial manifestation of hepatobiliary neoplasms is extremely rare. Three patients with PLA were identified from the ward registion files and were retrospectively reviewed. These patients (two men aged 74 and 80 years, and one woman aged 35 years) were treated (in the right lobe in two patients and in the left lobe in one) and subsequently followed up for 11-22 months. Two patients were diagnosed with hepatocellular carcinoma and one with metastatic cholangiocarcinoma. Two patients were subjected to biopsies showing features of inflammatory pseudotumor before a diagnosis of hepatocellular carcinoma. One patient underwent hepatic resection with good results. In the other two patients who declined any further interventions, one died a few weeks after diagnosis and the other is still alive on conservative treatment. This series of cases highlights the importance of considering underlying hepatobiliary malignancies in patients with PLA and a close follow-up necessary for non-resolving hepatic lesions.
    Hepatobiliary & pancreatic diseases international: HBPD INT 10/2009; 8(5):547-50. · 1.17 Impact Factor