A bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta-analysis. Psychosom Med.

Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, United Kingdom. .
Psychosomatic Medicine (Impact Factor: 4.09). 02/2008; 70(1):102-16. DOI: 10.1097/PSY.0b013e31815c1b71
Source: PubMed

ABSTRACT There is growing epidemiological literature focusing on the bidirectional association between psychosocial factors and atopic disorders, but no efforts to quantify the relationship systematically have been published.
We searched Medline, PsycINFO, Web of Science, and PubMed up to June 2007. The studies included were prospective cohort studies investigating the influence of psychosocial factors on atopic disorders and the effect of atopic disorders on mental health. Two investigators independently extracted data and determined study quality.
There were 43 studies (in 22 articles), of which 34 evaluated the effect of psychosocial factors on atopic disorders and 9 evaluated the effect of atopic disorders on mental health. The major atopic disease assessed in these studies was asthma (90.7%) with allergic rhinitis, 4.7%; atopic dermatitis, 2.3%; and food allergies, 2.3%. The overall meta-analysis exhibited a positive association between psychosocial factors and future atopic disorder (correlation coefficient (r) as combined size effect .024; 95% confidence interval, 0.014-0.035; p < .001) as well as between atopic disorders and future poor mental health (r = .044, 95% confidence interval, 0.021-0.067, p < .001). More notably, the subgroup meta-analysis on the healthy and atopic disorder populations showed psychosocial factors had both an etiological and prognostic effect on atopic disorders.
The current review revealed a robust relationship between psychosocial factors and atopic disorders. This supports the use of psychological in addition to conventional physical and pharmacological interventions, in the successful prevention and management of atopic disorders.

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Available from: Mark Hamer, Aug 18, 2015
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    Respiratory Physiology & Neurobiology 06/2015; 216. DOI:10.1016/j.resp.2015.05.013 · 1.97 Impact Factor
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    • "In adults with established asthma [37], distinct types of stress were not found to be associated with asthma morbidity, but early traumatic life events were shown to predict asthma at adult age [38]. A meta-analysis concluded that exposure to stressors alone does not increase the risk of allergic disorders, but only exposure to stressors that evoke negative cognition leads to an adverse impact on asthma patients [39]. These findings highlighted the importance of individual variation in perception of stressors, and the importance of perceived stress in the course of asthma. "
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    ABSTRACT: Purpose Psychiatric comorbidity is reported to be common among adolescents with asthma, but little is known about its underlying psychological factors. Objective This study explored the profile of anxiety and depressive comorbidities among adolescents with well-controlled and poorly controlled asthma and the contribution of neuroticism and perceived stress. Methods The Revised Child Anxiety and Depression Scale, Neuroticism subscale of Big Five Inventory, Perceived Stress Scale, and Asthma Control Test were administered to 198 adolescents (aged 12–19 years) with well-controlled (n = 137) and poorly controlled asthma (n = 61) as well as 171 healthy neighborhood controls. Results Adolescents with poorly controlled asthma, compared with well-controlled asthma patients and healthy controls, had higher scores of depression (p = .006), panic attacks (p = .002), total anxiety (p = .038), and total internalizing symptoms (p = .017), after adjusting for gender, age, ethnicity, smoking status, and family housing type. Adolescents with asthma had higher neuroticism (p = .025), perceived stress (p = .022), and body mass index (p = .006) and lower self-rated health (p < .001) than healthy controls. No significant differences in psychiatric comorbidity scores were observed after accounting for differences in underlying psychological and physical factors. Among asthma patients, increased asthma control was associated with decreased scores of psychiatric comorbidity (p < .01), but the association was not significant after allowing for decreased neuroticism and perceived stress. Conclusions The diagnosis of asthma and poor asthma control in adolescents is associated with excess psychiatric comorbidity, which is likely due to increased neuroticism and perceived stress.
    Journal of Adolescent Health 08/2014; DOI:10.1016/j.jadohealth.2014.01.007 · 2.75 Impact Factor
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    • "Nowadays, the studies of their relationship can be viewed from the standpoint of the biopsychosocial model of disease [1] [2] [3] [4] [5]. The model postulates that one needs to take into consideration the interaction between biological, psychological, and social factors to be able to understand different disease outcomes , i.e. vulnerability to disease, disease onset, expression of symptoms, disease progression, exacerbation, recovery, survival , and associated quality of life [8]. "
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    04/2014; 63(2). DOI:10.1016/j.ejcdt.2014.01.009
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