Diverticular disease increased steadily concomitant with elevated rates of overweight and obesity during the 20th century. Therefore, the objective of this study was to investigate whether overweight and obesity in midlife predict future diverticular disease in men.
This was a prospective cohort study of a general population of men living in Göteborg, Sweden. A community-based sample of 7,494 men, investigated when aged 47 to 55 years, were followed from baseline in 1970 to 1973 for a maximum of 28 years. Hospitalization with a discharge diagnosis of diverticular disease according to the Swedish hospital discharge register was measured.
Totally, 112 men (1.5 percent) were hospitalized with diverticular disease. A relationship between body mass index and diverticular disease was demonstrated; men with a body mass index between 20 and 22.5 kg/m2 had the lowest risk. After adjustment for covariates, the risk increased linearly in men who had a body mass index of 22.5 to 25 (multiple-adjusted hazard ratio, 2.3; 95 percent confidence interval, 0.9-6; 25-27.5 (hazard ratio, 3 (1.2-7.6)), 27.5-30 (hazard ratio 3.2, (1.2-8.6)), and 30 or greater (hazard ratio 4.4, (1.6-12.3)) kg/m2 (P for linear trend = 0.004). Men with a body mass index of < or =20 kg/m2 had a nonsignificantly elevated risk (hazard ratio, 3 (0.7-12.5)). Smoking (hazard ratio, 1.6 (1.1-2.3) and diastolic blood pressure (hazard ratio, 1.02 (1.01-1.04) per mmHg) also were independently related to risk of diverticular disease.
In a large community-based sample of middle-aged men, overweight and obesity were strongly linked to future severe diverticular disease leading to hospitalization.
"Asociación entre obesidad y sobrepeso con enfermedad diverticular complicada del colon, según diferentes autores Autor y año País Tipo de estudio Método de medición Conclusiones Dobbins et al. 13 (2006) Australia Retrospectivo IMC Los pacientes con diverticulitis recurrente y perforación, son significativamente más obesos que los asintomáticos y aquellos con un sólo episodio (p = 0,001 y p = 0,002) Rosemar et al. 14 (2008) Suecia Cohorte prospectivo IMC El sobrepeso y la obesidad se correlacionan con un myor incidencia de diverticulitis, que requiere de hospitalización (RR de 3 a 4.4) Strate et al. 12 (2009) Estados Unidos Cohorte prospectivo IMC, circunferencia de la cintura, y proporción cintura-cadera El sobrepeso y la obesidad se asociaron con una mayor incidencia de diverticulitis y hemorragia ( RR 1,78 y 3,19) Jeong et al. 15 (2011) Korea Retrospectivo IMC, medición de grasa visceral mediante TAC La obesidad visceral se asocia de manera significativa con enfermedad diverticular complicada (p = 0,032) Yamada et al. 16 (2013) Japón Retrospectivo IMC, medición de grasa visceral mediante TAC La obesidad visceral se asocia de manera significativa con diverticulitis izquierda (p = 0,0390) "
[Show abstract][Hide abstract] ABSTRACT: Left-sided diverticulitis is increasing in Japan, and many studies report that left-sided diverticulitis is more likely to be severe. Therefore, it is important to identify the features and risk factors for left-sided diverticulitis. We hypothesized that left-sided diverticulitis in Japan is related to obesity and conducted a study of the features and risk factors for this disorder in Japan.
Right-sided diverticulitis and left-sided diverticulitis patients (total of 215) were compared with respect to background, particularly obesity-related factors to identify risk factors for diverticulitis.
There were 166 (77.2%) right-sided diverticulitis patients and 49 (22.8%) left-sided diverticulitis patients. The proportions of obese patients (body mass index ≥25 kg/m(2), p=0.0349), viscerally obese patients (visceral fat area ≥100 cm(2), p=0.0019), patients of mean age (p=0.0003), and elderly patients (age ≥65 years, p=0.0177) were significantly higher in the left-sided-diverticulitis group than in the right-sided-diverticulitis group. The proportion of viscerally obese patients was significantly higher in the left-sided-diverticulitis group than in the left-sided-diverticulosis group (p=0.0390).
This study showed that obesity, particularly visceral obesity, was a risk factor for left-sided diverticulitis in Japan.
Gut and liver 09/2013; 7(5):532-8. DOI:10.5009/gnl.2013.7.5.532 · 1.81 Impact Factor
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