The ventral striatum as an interface between the limbic and motor systems.
VU University Medical Center, Department of Anatomy and Neurosciences, Amsterdam, Netherlands.CNS spectrums (Impact Factor: 1.3). 01/2008; 12(12):887-92.
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ABSTRACT: Aggregation of functional magnetic resonance imaging (fMRI) data in regions-of-interest (ROI) is required for complex statistical analyses not implemented in standard fMRI software. Different data-aggregation methods assess various aspects of neural activation, including spatial extent and intensity. New method: In this study, conducted within the framework of the PREDICT study, we compared different aggregation measures for voxel-wise fMRI activations to be used as prognostic factors for relapse in 49 abstinent alcohol-dependent individuals in an outpatient setting using a cue-reactivity task. We compared the importance of the data-aggregation measures as prognostic factors for treatment outcomes by calculating the proportion of explained variation. Results and comparison with existing method(s): Relapse risk was associated with cue-induced brain activation during abstinence in the ventral striatum (VS) and in the orbitofrontal cortex (OFC). While various ROI measures proved appropriate for using fMRI cue-reactivity to predict relapse, on the descriptive level the most "important" prognostic factor was a measure defined as the sum of t-values exceeding an individually defined threshold. Data collected in the VS was superior to that from other regions. In conclusion, it seems that fMRI cue-reactivity, especially in the VS, can be used as prognostic factor for relapse in abstinent alcohol-dependent patients. Our findings suggest that data-aggregation methods that take both spatial extent and intensity of cue-induced brain activation into account make better biomarkers for predicting relapse than methods that consider an activation's spatial extent or intensity alone. NCT00317031. Copyright © 2015. Published by Elsevier B.V.Journal of Neuroscience Methods 01/2015; 242. DOI:10.1016/j.jneumeth.2015.01.001 · 1.96 Impact Factor
08/2013; 17(4):106-112. DOI:10.1007/s12474-013-0020-1
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ABSTRACT: A large number of imaging studies have examined the neural correlates of consummatory pleasure and anticipatory pleasure in schizophrenia, but the brain regions where schizophrenia patients consistently demonstrate dysfunctions remain unclear. We performed a series of meta-analyses on imaging studies to delineate the regions associated with consummatory and anticipatory pleasure dysfunctions in schizophrenia. Nineteen functional magnetic resonance imaging or positron emission tomography studies using whole brain analysis were identified through a literature search (PubMed and EBSCO; January 1990-February 2014). Activation likelihood estimation was performed using the GingerALE software. The clusters identified were obtained after controlling for the false discovery rate at p<0.05 and applying a minimum cluster size of 200mm(3). It was found that schizophrenia patients exhibited decreased activation mainly in the rostral medial prefrontal cortex (rmPFC), the right parahippocampus/amygala, and other limbic regions (e.g., the subgenual anterior cingulate cortex, the putamen, and the medial globus pallidus) when consummating pleasure. Task instructions (feeling vs. stimuli) were differentially related to medial prefrontal dysfunction in schizophrenia. When patients anticipated pleasure, reduced activation in the left putamen was observed, despite the limited number of studies. Our findings suggest that the medial prefrontal cortex and limbic regions may play an important role in neural dysfunction underlying deficits in consummatory pleasure in schizophrenia. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.Psychiatry Research Neuroimaging 01/2015; 231(3). DOI:10.1016/j.pscychresns.2015.01.001 · 2.83 Impact Factor
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